GHS Classification Result

Chemical Name：1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide
CAS：133-06-2

Result：
ID: 862
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Calculated based on the following data: Rat LD50 value:6170mg/kg, about 9000mg/kg and 3573mg/kg (all are Agricultural-Chemicals abstracts). Since the calculated values was 3677mg/kg, it was classified to category 5.
1 Acute toxicity （Dermal） Not classified - - - - Based on rat LD50 value: >5000mg/kg (Agricultural-Chemicals abstracts), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on male rats LC50 (4 hours) level: 0.72mg/L (Agricultural-Chemicals abstracts), it was set as Category 3.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was set as Category 2 from description that moderate to severe erythema and that accompanied by dropsy were acknowledged as a result of sticking on human skin for 24 hours (Agricultural-Chemicals abstracts).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		There is the description that in the eye irritation tests using the rabbit, the change of the eye, which indicates irritation was acknowledged, and was maintained for 21 days (Agricultural-Chemicals abstracts). So it was set as Category 1.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Since positive rates were 40% in maximization test using guinea pigs (Agrichemical Abstracts), we categorized it as Category 1.
5 Germ cell mutagenicity Not classified - - - - There is a negative result in the dominant lethal examination on rats and mice and the specific locus examination on mice. Furthermore, although there was a positive result with the chromosome aberration test on mouse spermatogenous cell which is an in vivo mutagenicity test using germ cells, the increased chromosomal aberrations of spermatogonium was observed only in the high-dose groups. And with low-dose, the increase in heterochromosome or micronucleus was not observed with the chromosome aberration test and micronucleus examination on mouse bone marrow cells (Agricultural-chemicals abstract), and the in vivo micronucleus examination was estimated to be negative in JMPR. So it was classified as out of Category.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into the group 3 (IARC Suppl.7, 1987) in IARC. But it is classified into A3 (ACGIH, 2002) in ACGIH, and category 3 (EU-Annex I, 2006) in EU. So it was considered as Category 2 according to ACGIH which is latest assessment document.
7 Reproductive toxicity Not classified - - - - It was considered as out of Category since specific reproductive toxicity was not observed at the dose causing general toxicity to parental animals in the rat feeding oral administration reproductive test and an pregnant rat, rabbit, monkey and hamster oral administration test (all are agricultural-chemicals abstracts).
8 Specific target organ toxicity - Single exposure Not classified - - - - Since any serious toxic effect by the dose exceeding the guidance value range of Category 2 was not seen in oral administration, dermal administration, or inhalation exposure test using rats and mice (Agricultural-Chemical abstracts), it was set as the outside of Category.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - In the oral study using a rat, mice and dogs, since the serious toxic effects were not observed with the dosage exceeding the Category 2 guidance value range (Agricultural Chemicals abstracts), it was classified into the outside of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=50microg/L of fishes (Rainbow trout) (Agricultural Chemical Registration Data, 1991).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though supposed less bioaccumulative (log Kow=2.8 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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