GHS Classification Result

Chemical Name：Propane, 1,2,3-trichloro-
CAS：96-18-4

Result：
ID: 859
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: >60degC and <=93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 304degC (ICSC (J), 2002)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Calculated based on rat LD50 values: 150mg/kg (CICAD 56, 2003, DFGOT vol.9, 1998, ATSDR, 1992), 500mg/kg (CICAD 56, 2003), 444mg/kg (ACGIH 7th, 2001, DFGOT vol.9, 1998, NTP TR384, 1993, ATSDR, 1992), 505mg/kg (ACGIH 7th, 2001), 205mg/kg (DFGOT vol.9, 1998), 170mg/kg (DFGOT vol.9, 1998), 150mg/kg (DFGOT vol.9, 1998), 442mg/kg (DFGOT vol.9, 1998), 250mg/kg (DFGOT vol.9, 1998), and 320mg/kg (IARC 63, 1995). Since the calculated values was 253mg/kg, it was set as Category 3.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The calculation value was 352mg/kg based on rabbit LD50 = 384mg/kg (CICAD 56, 2003), 2457mg/kg (CICAD 56, 2003, ACGIH 7th, 2001, DFGOT vol.9, 1998, NTP TR384, 1993), 900mg/kg (DFGOT vol.9, 1998), 850mg/kg (DFGOT vol.9, 1998), 850mg/kg (DFGOT vol.9, 1998), 516mg/kg (DFGOT vol.9, 1998), and 250mg/kg (DFGOT vol.9, 1998). Rat LD50 value is 836mg/kg (CICAD 56, 2003, DFGOT vol.9, 1998, ATSDR, 1992). The lower value was adopted, and it was set as Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on rat LC50 (4 hours) value: about 3mg/L (CICAD 56, 2003), its vapor pressure indicate steam with almost no mist, and it was classified by the ppm concentration standard. Since 3mg/L was converted to 498ppm using the conversion factor (1ppm=6.03mg/m3), it was classified as Category 2.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - It was carried out the outside of Category from description that the skin of the rabbit was not stimulated on ACGIH (7th, 2001), and description that irritation was not admitted in the test applied to the rabbit skin for 4 hours on CICAD 56 (2003).
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is description that in the test applied to the eye of the rabbit, mild irritation or the change of the eye recovered within seven days, were acknowledged (CICAD 56 (2003) and DFGOT (vol.9, 1998)). But also have the description that in the eye of the rabbit, moderate or strength irritation are acknowledged (CICAD 56 (2003) and ACGIH (7th, 2001)). So the subdividing was not possible, and it was set as Category 2A-2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - We classified it as Out of Category based on the description that it did not show sensitizing property in the Buehler test using the guinea pigs in CICAD 56 (2003), DFGOT (vol.9, 1998) and ATSDR (1992).
5 Germ cell mutagenicity Not classified - - - - Since there were negative results with the dominant lethal test on rats, which is an in vivo generation mutagenicity test using germ cells (CICAD 56, 2003, ACGIH 7th, 2001, DFGOT vol.9, 1998, IARC 63, 1995, NTP TR384, 1993, ATSDR, 1992), it was classified as out of Category.
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into A3 (ACGIH (7th, 2001)) in ACGIH, it was classified into group 2A (IARC 63, 1995) in IARC, 2A (industrial hygene academic society recommentation, 2005) in Japan Assoc. of Industrial Health, R (NTP RoC 11th, 2005) in NTP, and category 2 (EU-Annex I, 2005) in EU. So it was was considered as Category 1B based on the evaluation including IARC and updated evaluation (NTP, 2005).
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into Category 1B based on the description that reduction of the female reproduction ability was observed at the dose causing general toxicity to parental animals in the mouse one-generation reproductive oral administration study(IARC 63 (1995), NTP DB (2005), CICAD 56 (2003)).
8 Specific target organ toxicity - Single exposure Category 1 (liver), Category 2 (adrenal gland), Category 3 (narcotic effects, respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (liver)
H371: May cause damage to organs (adrenal gland)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		It was set as Category 1 (liver) from description that the effect which indicates a liver injury in the inhalation exposure test of CICAD 56 (2003), ACGIH (7th, 2001), and NTP TR384 (1993) using the rat was acknowledged in the concentration of the guidance value range of Category 1. It was set as Category 2 (adrenal).from description that the effect on the adrenal was acknowledged by exposure of the guidance value range of Category 2 in the inhalation exposure test using the rat and guinea pig (ACGIH (7th, 2001), NTP TR384 (1993)). Moreover, description that the anesthetic actions was admitted in the inhalation exposure test using the rat and guinea pig (ACGIH (7th, 2001), NTP TR384 (1993)), description that respiratory irritant was admitted in the inhalation exposure test using the rat and mouse (ACGIH (7th, 2001)), and from description that irritation was admitted in the throat by evidence of exposure of humans (CICAD 56 (2003), ACGIH (7th, 2001), DFGOT (vol.9, 1998), IARC 63 (1995) ATSDR (1992)), and it was set as Category 3 (an anesthetic actions, respiratory irritant).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, respiratory system, blood), Category 2 (kidney, heart) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (liver, respiratory system, blood)
H373: May cause damage to organs through prolonged or repeated exposure (kidney, heart) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that in the the 13-week inhalation exposure test using the rat, the effects on the liver and blood, and the effects which suggests anemia were observed with the concentration in the Category 1 guidance value range (CICAD 56 (2003), ACGIH (7th, 2001), DFGOT (vol.9, 1998), IARC 63 (1995), NTP TR384 (1993), ATSDR (1992)), it was classified into Category 1 (liver, respiratory systems, blood). Moreover, the description that in the 13-weeks administration tests in drinking water or the 17-weeks oral administration tests using the rat , the effects on the kidney were observed with the dosage in the Category 2 guidance value range (CICAD 56 (2003), ACGIH (7th, 2001), DFGOT (vol.9, 1998), IARC 63 (1995), NTP TR384 (1993), IRIS (2005), ATSDR (1992)), furthermore, the description that in the 90-days oral administration test using the rat, the effects on the myocardial were observed with the dosage in the Category 2 guidance value range (CICAD 56 (2003), DFGOT (vol.9, 1998), IARC 63 (1995)), it was classified into Category 2 (kidney, heart).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour EC50=4.1mg/L of Crustacea (Daphnia magna) (CICAD 56 and 2003).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bio-accumulative (BCF=13 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

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