GHS Classification Result

Chemical Name：Methoxychlor
CAS：72-43-5

Result：
ID: 858
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available by regulated examination methods, though "Flammable" (ICSC (J) (1999))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although there is information that it corrodes irons and aluminum slightly (HSDB (Access on Jan. 2006)), test methods suitable for a solids material are not established.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Calculated based on rat LD50 values: 5000 - 6000 mg/kg (ACGIH 7th, 2001), 5000 - 7000 mg/kg (IARC 20, 1979), and 3460 - 7000 mg/kg (ATSDR, 2002). Since the calculated value was 4325mg/kg, it was set as Category 5.
1 Acute toxicity （Dermal） Not classified - - - - They were set as the outside of Category based on rat and rabbit LD50 values: all 6000mg/kg (PD, 2006).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - No data available
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - We classified it as Out Of Category based on the description that it has almost or completely no skin sensitizing property in ACGIH (7th, 2001).
5 Germ cell mutagenicity Not classified - - - - There was a negative result with the chromosome aberration test on mice sperm cells, which is an in vivo mutagenicity test using germ cells, and chromosome aberration test on mice marrow cells, which is an in vivo mutagenicity test using somatic cells (ATSDR, 2002). So it was classified as out of Category.
6 Carcinogenicity Not classified - - - - It is classified into group 3 (IARC Suppl.7, 1987) in IARC, A4 (ACGIH 7th, 2001) in ACGIH and D (IRIS, 2006) in EPA in 1990. So it was considered as the outside of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into Category 2 based on the description that reduction of fertility was observed at the dose occuring general toxicity to parental animals in the rat oral administration reproductive study (ACGIH (7th, 2001), IRIS (2006), and ATSDR (2002)).
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 2 (nerve systems) from description that the influence of the nervous systems, such as tremors, convulsions, paralysis, etc. was acknowledged in the doses of the guidance value range of Category 2 in the oral study using the rat of ATSDR (2002).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, nervous system, endocrine system) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, nervous system, endocrine system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that in the feeding oral administration tests using the rat, edema, necrosis and congestion of the liver were observed with the dosage in the Category 2 guidance value range (IRIS (2006)), the description that in feeding oral administration tests using the dog, the effects on the nervous systems, such as tremors and spasms, etc., were observed with the dosage in the Category 2 guidance value range (IARC 20 (1979)), and the dedscription that in the oral study using the rat or mouse, effects on the endocrine systems, such as increases in the prolactin level in pituitary, increased levels of hypothalamic GnRH (gonadotropin releasing hormones), and females menstrual cycle abnormalities, were observed with the dosage in the Category 2 guidance value range (IRIS (2006), NTP DB (2006), ATSDR (2002)), it was classified into Category 2 (liver, nervous systems, endocrine systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour LC50=0.78microg/L of Crustacea (Water flea) (HSDB, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=5.08 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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