GHS Classification Result

Chemical Name：Ethane, 1,1,2-trichloro-1,2,2-trifluoro-
CAS：76-13-1

Result：
ID: 855
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: none (Lange, 14th, 1992), non-combustible (Solvent Pocket Book, 1994), or flame-retardant (Hommel, 1991, Card No.199)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - They are nonflammables or flame retardants. (a pocket book books (1994), Hommmel (1991) Card No.199)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - They are nonflammables and flame retardants. (solvent pocket book (1994), Hommmel (1991) Card No.199)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine and fluorine (but not oxygen) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - Non-corrosive to metals (Solvent Pocket Book, 1994)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on rat LD50 value: 43g/kg (ACGIH, 7th (2001), Japan Society for Occupational Health advice (1993), DFGOT vol.3 (1999), CERI Hazard Data, (1999), RTECS (2005), IUCID (2000)), it was set as the outside of Category.
1 Acute toxicity （Dermal） Not classified - - - - Based on the data that lethal dose of rabbits is 11000mg/kg or exceeds it (ACGIH (2991), CERI Hazard Data (1999), and RTECS (2005), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Based on calculated value = 397.68mg/L, it was judged as LC50 value with exposure to vapor with almost no mist. Standard values for ppm concentrations was applied, and it was classified as out of Category. 397.68mg/L is statistically calculated value from 3 rat LC50 values (4 hour exposure): 52000ppm (Industrial Hygiene Society (1993) and CERI Hazard Data (1999)), 52500ppm (EHC 113 (1990)), 68000ppm (Industrial Hygiene Society (1993) and CERI Hazard Data (1999)) (since the statistically calculated value was lower than the lowest value of the data, adopted the lowest data of 52000ppm)
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on description that mild irritation was admitted in the skin irritation study by the Draize method (24-hour exposure) in a rabbit (CERI Hazard Data, 1999), it was set to Category 3.
3 Serious eye damage/eye irritation Not classified - - - - Since in the test using a rabbit, irritation was not reached the acceptance criteria (DFGOT vol.3, 1999), and was not seen (CERI Hazard Data in 1999), it was set as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although it showed negative for the Maximization method in the guinea pigs (CERI Hazard Data, 1999), we presupposed that it could not be classified for the insufficiency of data, since there was no description which otherwise negates skin sensitization clearly.
5 Germ cell mutagenicity Not classified - - - - There are descriptions of negative result with dominant lethal test on mice, which is an in vivo generation mutagenicity test using germ cells, (EHC 113 (1990), ACGIH (7th, 2001), DFGOT vol.3 (1999), and CERI Hazard Data (1999)), and there is no report of in vivo examination. So it was classified as out of Category.
6 Carcinogenicity Not classified - - - - Since it was classified into A4 in ACGIH (ACGIH 7th, 2001), it was considered as the outside of Category.
7 Reproductive toxicity Not classified - - - - It was considered as out of Category based on the description that it is not observed effects on embryotoxicity/fetotoxicity and teratogenecity in rat organogenetic period inhalation exposure test at dose causing general toxicity to maternal animal (EHC 113 (1990)), ACGIH (7th, 2001), in the description with CERI Hazard Data (1999)), and the description of no abnormality in standard reproductive items in the rat inhalation exposure one-generation reproductive test ) (EHC 113 (1990), ACGIH (7th, 2001), CERI Hazard Data (1999))).
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation, Narcotic effects） Warning H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In volunteers or accidents by evidence of exposure on humans, description that the symptoms accompanied to the transient reduction of psychomotricite, drowsiness, dizziness, memory impairments, symptoms accompanied to theanesthesia action etc., respiratory irritation was acknowledged (EHC 113 (1990), DFGOT vol.3 (1999)), and from the description that respiratory irritant and anesthetic actions were acknowledged inhalation exposure in a rat, a guinea pigs, and a dog (ACGIH (7th, 2001)), DFGOT vol.3 (1999) and CERI Hazard Data (1999)). So it was set as Category 3 (respiratory irritation, anesthesia action) .
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the description that in humans of the long term occupational exposure, neuropsychological symptoms, disability in the psychological work tests, and the liver dysfunctions accompanied by fatty infiltrations in the liver were observed (industrial hygiene society reccomendation(1994), CERI Hazard Data(1999)), it was classified into Category 1 (central nervous systems, liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour EC50=4290microg/L of Crustacea (Daphnia magna) (MOE Risk Assessment No.3, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and not rapidly degrading (BOD: 2% (existing chemical safety inspections data)), though less bio-accumulative (BCF=86 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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