GHS Classification Result

Chemical Name：Triethanolamine
CAS：102-71-6

Result：
ID: 853
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - It is known not to ignite spontaneously from the experience in manufacturing or treatment, even if it contacts the normal temperature air.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Calculated based on rat LD50 values: 8680mg/kg, 9110mg/kg (ACGIH 7th, 2001), 8000 to 9110 mg/kg (PATTY 4th, 1994), 8000 to 9000 mg/kg, and 4200 to 11300 mg/kg (NTP TR 518, 2004). Since the calculated value was 7269.3 mg/kg, it was set as the outside of Category.
1 Acute toxicity （Dermal） Not classified - - - - Since death was not acknowledged in the test in which 2000mg/kg was dermally exposed for 24 hours to skin of rabbits (NTP TR 518 (2004)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was set as Category 2 from description that skin irritation was acknowledged by high exposure levels or repeated exposure in the humans (ACGIH (7th, 2001), SIDS (2005), IARC 77 (2000), NTP TR 518 (2004)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is the description that in the eye irritation tests using the rabbit, irritation was asknowledged and it recovered completely 14 days afterward (ACGIH (7th, 2001), PATTY (4th, 1994), and NTP TR 518 (2004)). So it was set as Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		We classified it as Category 1 based on the description that there are reports of allergic contact dermatitis in human in ACGIH (7th, 2001), IARC 77 (2000), and NTP TR 518 (2004).
5 Germ cell mutagenicity Not classified - - - - Since there was a negative result with the micronucleus test on mice red corpuscles which is a in vivo mutagenicity test using somatic cells (IARC 77, 2000 and NTP TR 518, 2004), it was classified as out of Category.
6 Carcinogenicity Not classified - - - - Since it was classified into the group 3 in IARC 77 (2000), it considered as the outside of Category.
7 Reproductive toxicity Not classified - - - - It was considered as out of Category based on the description that effect was not observed on sperm and the female estroul cycle in the rat or mouse 13-weeks dermal administration test at dose of 2000mg/kg or more (IARC 77 (2000)), description that affect to a fetal/pup was not observed in the pregnant mouse oral administration test at dose of 1125mg /kg (NTP TR 518 (2004)), and the description that affect was not observed on fertile potential and to offsprings in the test which carried out dermal administration of the 500mg/kg to the ratand 2000mg/kg to mice from premating to lactation periods ends (IARC 77 (2000) and NTP TR 518 (2004) ) .
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 (respiratory irritant) from description that vapor stimulates a nose as effect on the humans in NTP TR 518 (2004).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - Regarding the descriptions that major toxicity was not observed in dermal, oral, or an inhalation exposure test using rats, mice, or guinea pigs with the given dose of the guidance value range of Caegory 2, and it was set to out of Category (ACGIH (7th, 2001), PATTY (4th, 1994), in IARC 77 (2000) and NTP TR 518 (2004)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 96-hour ErC50=169mg/L of algae (Scenedesmus) (IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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