GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：N-methyl-N,2,4,6-tetranitroaniline
CAS：479-45-8
Result：
| ID: | 846 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Division 1.1 |
|
Danger | H201: Explosive; mass explosion hazard |
P370+P380: In case of fire: Evacuate area. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P230: Keep wetted with ... P240: Ground/bond container and receiving equipment. P250: Do not subject to grinding/shock/.../friction. P280: Wear protective gloves/protective clothing/eye protection/face protection. P372: Explosion risk in case of fire. P374: Fight fire with normal precautions from a reasonable distance. P401: Store ... P501: Dispose of contents/container to ... |
UNRTDG Class: 1.1D |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | UNRTDG Class: 1.1 |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Classified in explosives |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | UNRTDG Class: 1.1 |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | UNRTDG Class: 1.1 |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not classified | - | - | - | - | UNRTDG Class: 1.1 |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Not classified because of SPECIES: Rat;LDLo VALUE: :5000mg/kg; REFERENCE SOURCE: RTECS (2005) |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on rabbit LD50 value: >2000mg/kg (RTECS, 2005), it was set as the outside of Category. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
It was set as Category 2 from description that there was skin irritation as effect of the humans (ACGIH (7th, 2001), PATTY (4th, 1994), DFGOT (vol.1, 1998)). |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
There is the description that in the test applied to the eye of the rabbit (RTECS (2005)), severe irritation was acknowledged. So it was set as Category 2A. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Although there were descriptions that asthmatic symptoms was acknowledged in the cases of human occupational exposure and there is possibility of sensitizing properties for respiratory organs in ACGIH (7th, 2001), DFGOT (1 vol. 1998), and ATSDR (1995), we presupposed that we could not classify it because of insufficiency of data, since these cases were not concluded to be positive. |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
We classified it as Category 1 because it is classified to be Sh according to DFG (MAK/BAT, 2004), and there were case reports of allergic contact dermatitis in ACGIH (7th, 2001), DFGOT (1 vol. 1998), PATTY (4th, 1994), and ATSDR (1995) for cases of human exposure. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） |
|
Warning | H335: May cause respiratory irritation (respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
It was set as Category 3 (respiratory irritant) from description that respiratory irritant is acknowledged in humans evidence of exposure of ACGIH (7th, 2001), PATTY (4th, 1994), DFGOT (vol.1, 1998), and ATSDR (1995). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver, blood, central nervous system, respiratory system), Category 2 (kidney) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (liver, blood, central nervous system, respiratory system) H373: May cause damage to organs through prolonged or repeated exposure (kidney) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on descriptions that myelosuppression, hepatotoxicity, and influence of the central nervous systems such as headache, lassitude, insomnia, etc. are observed in humans with exposure (PATTY (4th, 1994)), that, in evidence of human occupational exposure, a liver damages, anemia, asthmatic symptoms such as nocturnal paroxysmal coughings and dyspnea, and the lung tissue disorders wereobserved (ACGIH (7th, 2001), DFGOT (vol.1, 1998) and ATSDR (1995)), that in the oral study using rats, increase in methemoglobin, decrease in hemoglobin and renal tubular degeneration were observed with the given dose of the guidance value range of Category 2 (DFGOT (vol.1, 1998)), it was classified into Category 1 (liver, blood, a central nervous systems, the respiratory system) and Category 2 (kidney). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |