GHS Classification Result

Chemical Name:1,1,2,2-tetrabromoethane
CAS:79-27-6

Result:
ID: 843
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: >93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - The ignition points is 335 degC. (Hommmel (1991) Card No.215)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 6.1
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 6.1

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
It was set to as Category 4 based on rat oral LD50: 924mg/kg (Health, Labor and Welfare Ministry reports (2005)).
1 Acute toxicity (Dermal) Not classified - - - - Based on rat dermal LD50: 5250mg/kg (RTECS (2005), HSDB (2005)), it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on rat 4-hour inhalation LC50: 0.549mg/L (38.9ppm) (RTECS (2005), HSDB (2005)), it was judged as steam vapor pressure with this concentration. So it was classified as Category 1.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
It was set as Category 2 from description that the skin of the humans was stimulated (ICSC (J) (1995), HSDB (2005), SITTIG (47th, 2002), DHP (13th, 2002)), and description that edema and bullous were seen within 24 hours by blocked applications of several hours with the rabbit (PATTY (4th, 1994)).
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
There is the description that the eyes of the humans are stimulated (ICSC (J), (1995), HSDB (2005), SITTIG (47th, 2002), and DHP (13th, 2002)), and the description that in the rabbit, mild irritation was seen in the eyes (RTECS (2005), and HSDB (2005)). So it was set as Category 2A-2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Since there are no in vivo mutagenicity or genotoxicity study data on germ or somatic cells, and there is only negative data with in vitro mutagenicity test. So it cannot be classified.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (central nervous system)
H335: May cause respiratory irritation (respiratory tract irritation)
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Description that the same disorder as a solvent induced encephalopathy was strongly suggested by the central nervous system function tests of the human acute evidence of exposure of HSDB (2005), and from description that central nervous systems manifestations was developed with the dose equivalent to Category 2 in the single-dose oral study in rats by the Health, Labor and Welfare Ministry reports (2005), and the rats single times mist inhalation studies of PATTY (4th, 1994), and these were judged that specific target organs were a central nervous systems, and it was set as Category 2. From description of ICSC (J) (1995), SITTIG (47th, 2002), and DHP (13th, 2002) that the airway is stimulated, it judged that there was airway stimulativeness and was set as Category 3.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, lung), Category 2 (thyroid) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (liver, lung)
H373: May cause damage to organs through prolonged or repeated exposure (thyroid)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on descriptions that effect was obsesrved at liver with dose from 20mg/kg/day and at thyroid with dose from 60mg/kg/day in the 28-day oral study of rats (the Health, Labor and Welfare Ministry reports (2005)); and that in the 100 to 106-day inhalation exposure test to rats, by 7-hour per day exposure of 14 ppm vapor , effect was observed in liver and lungs (PATTY (4th, 1994)), it wasclassified into Category 1 (liver, lung) and Category 2 (thyroid).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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