GHS Classification Result

Chemical Name：Tetrahydrofuran
CAS：109-99-9

Result：
ID: 842
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: <23degC, Initial boiling point: >35degC, UNRTDG Class: 3, PG II
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - The ignition points is 321 degC (incompatible hazards Hb (2nd edition, 1997) p391).
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 3
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Liquid (GHS definition)
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3, PG II

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		It was set as Category 4 based on LD50= 1851mg/kg. This value calculated from rat oral LD50= 1650mg/kg (CERI Hazard Data (1999)), 2045mg/kg (ACGIH (7th, 2001)), 2845mg/kg (ACGIH (7th, 2001)) and 3200mg/kg (ACGIH (7th, 2001)).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Rat inhalation LC50 (3 hours) = 21000ppm (CERI Hazard Data (1999)) [equivalent 61.95mg/L]. By this concentration, it was judged as steam vapor pressure. And since 4-hour equivalent was 53.65mg/L, it was classified as out of Category.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was set as Category 2 from description that there was skin irritation as affect of the humans (CERI Hazard Data (1999), ACGIH (7th, 2001)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description that there is irritation to the eyes as the effect of the humans (CERI Hazard Data (1999) and ACGIH (7th, 2001)), it was set as Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Based on the description that no sensitizing property was found for the mammalian toxicity test results of CERI Hazard Data (1999), we classified it as Out Of Category.
5 Germ cell mutagenicity Not classified - - - - Since chromosome aberration test on mouse bone marrow cells (CERI Hazard Data (1999) and NTP TR475 (1998)) and sister chromatid exchange test on mouse bone marrow cells (NTP TR475 (1998)), which are in vivo tests, it was classified as out of Category by the technical policy.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Not classified - - - - It was considered as out of Category based on the description of rat (CERI Hazard Data (1999) and (NTP TR475 (1998))), and the description (ACGHI (7th, 2001)), and the description that it is not reported no effects on reproductive function and potential but no report of fetal malformation in rat reproductive test (IUCLID (2000)) and it is observed of increase of dead fetuses and fetal absortion in pregnant mouse 6-17 days inhalation exposure test with dose affecting maternal animals( CERI Hazard Data (1999) and NTP (NTP DB, 2005)).
8 Specific target organ toxicity - Single exposure Category 2 (nervous system), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		In inhalation exposure of the rat for 5000ppm 3 hours (4-hour equivalent 12.7mg/L) of CERI Hazard Data (1999), from the description that catalepsy posture, a coma, a clonic convulsion, pant breathing, and breathing difficulty were acknowledged, it was thought that it had effect on a nervous systems by the moderate exposure concentrations. And it was set as Category 2. From the descriptions that there is irritation to mucosa as affect on the humans written in CERI Hazard Data(1999) and ACGIH (7th, 2005), and vapor written in SITTIG (47th, 2002), ICSC (J) (1997), HSDB (2005), and HSFS (1997) stimulates a respiratory tracts, it was considered respiratory irritant and set as Category 3. Although there is a description (CERI Hazard Data (1999) and advice of industrial hygene academic society (2005)) that the anesthetic actions was acknowledged in the animal experiments, it was generated only in high concentrations as compared with the acute toxicities lethal doses, and it was judged as secondary effects. Moreover, in the human acute exposure, the central inhibition symptoms which suggests an anesthetic actions was not reported. And it was not thought that there was an anesthetic actions by humans.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, kidney, nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on descriptions that in occupational evidence of exposure, nephrosis, liver damage and a central spasm are observed (CERI Hazard Data (1999)), and that occupational evidence of exposure, nephrosis, liver damage, a central spasm, and peripheral neuropathy are observed (ACGIH (7th, 2001)), target organ were considered to be kidney, liver and nervous systems, and were classified into Category 1. [special notes] Although there was description that the slight obstacle at nose and tracheal epithelium was observed with 200 ppm (equivalent to 0.6 mg/L) exposure in 12-week inhalation study of rats (ACGIH (7th, 2001)); since it was slight impact, it was considered as an impact which does not endorse a classification.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - it carried out the outside of Category from 96-hour LC50=2160mg/L of fishes (Fathead minnows), and others (CERI Hazard Data, 2000) .
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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