GHS Classification Result

Chemical Name：2,3,7,8-tetrachlorodibenzo[b,e][1,4]dioxin
CAS：1746-01-6

Result：
ID: 838
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 1 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 1 based on rat LD50 values: 0.022mg/kg (PATTY 4th, 1994, IARC 69, 1997, NTP TR209, 1982, ATSDR, 1998), 0.013mg/kg (IARC 69, 1997), 0.043mg/kg (IARC 69, 1997, ATSDR, 1998), 0.34mg/kg (IARC 69, 1997), 0.100mg/kg (NTP TR209, 1982), 0.190mg/kg (NTP TR209, 1982), 0.125mg/kg (NTP TR209, 1982, ATSDR, 1998), 0.060mg/kg (ATSDR, 1998), and 0.164mg/kg (ATSDR, 1998).
1 Acute toxicity （Dermal） Category 1 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 1 based on rabbit LD50 value: 0.275mg/kg (PATTY 4th, 1994, IARC 69, 1997, ATSDR, 1998).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		From description that hyperkeratosis and epidermal hyperplasia were accepted in the acute dermatitis exposure tests using the mouse (ATSDR (1998)), and description that the skin was stimulated (ICSC (J) (2003)), it was set as Category 2.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is the description that in the test applied to the ocular of the rabbit (ATSDR (1998)), inflammation such as conjunctival edemas was acknowledged. So it was set as Category 2A-2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there was a positive result in the chromosome aberration test on rat and mouse marrow cells which is an in vivo mutagenicity test with somatic cells (ATSDR, 1998), and there was no positive result in the in vivo heredity toxicity examination on germ cells. So it was classified as Category 2 .
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into group 1 (IARC 69, 1997), and classified into 1 in Japan Assoc. of Industrial Health (industrial hygene academic society recommentation, 2005) and classified into K in NTP (NTP RoC 11th, 2005). So it was considered as Category 1A.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into Category 1B based on the description that reduced fertility potential was admitted in the rat fecundity study (IARC 69 (1997), ATSDR (1998), NTP TR209 (1982)), description that embryonic lethality effects, fetal malformation, and reduction of newborn baby's immunity and fertility potential, etc. were observed also in single exposure, and in the pregnant rat, mouse or hamster oral administration examination (IARC 69 (1997), ATSDR (1998), NTP TR209 (1982),) and description that fetotoxicity was observed at dose lower than causing maternal toxicity in the monkey oral administration examination (IARC 69 (1997) and ATSDR (1998)).
8 Specific target organ toxicity - Single exposure Category 1 (skin, liver, immune system, endocrine system, bone marrow, genitalia, urinary organs) Danger H370: Causes damage to organs (skin, liver, immune system, endocrine system, bone marrow, genitalia, urinary organs) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		As effect by human disaster exposure of IARC 69 (1997), description that chlorance, liver-enzymes change, change of an immune systems or glucose metabolism is admitted, the description that chlorance and the effect of liver is admitted by acute exposure in humans of ATSDR (1998), and in the oral study using the guinea pigs, rats, mice and a monky of IARC 69 (1997), ATSDR (1998),NTP TR (1982), description that the effect on the immune systems thymic atrophy, etc, effect on liver such as enlargement of liver cells or vacuolation, etc., epithelium fault formation of a renal pelvis, a ureter, and a bladder, marrow, and the cell reduction in deferent, from description that the effect of the endocrine systems on changes of thyroid hormones etc. was admitted with the given dose of the guidance value range of Category 1. So it was set as Category 1 ( skin, liver, an immune systems, an endocrine systems, marrow, genitals, urinary organs)
9 Specific target organ toxicity - Repeated exposure Category 1 (skin, liver, immune system, endocrine system, nervous system, blood, kidney) Danger H372: Cause damage to organs through prolonged or repeated exposure (skin, liver, immune system, endocrine system, nervous system, blood, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on descriptions that as effect of the human occupational exposure, chloracne, in liver-enzymes change, description that change of an immune systems or sugar metabolism is observed (IARC 69 (1997)), and humans evidence of exposure, hepatotoxicity, the effect of the endocrine systems on the skin influences of chloracne etc., sugar metabolism, thyroid dysfunction, etc., and the symptoms in peripheral and a central nervous systems are observed (ATSDR (1998)), and also that in the oral study using rat,mice or guinea pigs, the effect of the immunity systems on thymic atrophy etc., the denaturation of the effect of the blood on a liver damages, a thrombocytopenias, etc., the kidney, and the thyroid gland was obsserved with the given dose of the guidance value range of Category 1 ( IARC 69 (1997), ATSDR (1998),NTP TR209 (1982)), and it was classified into Category 1 (the skin, liver, an immune systems, an endocrine systems, a nervous systems, blood, kidney)
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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