GHS Classification Result

Chemical Name:fthalide
CAS:27355-22-2

Result:
ID: 836
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - SPECIES: Rat ENDPOINT: LD50 VALUE: > 10000 mg/kg REFERENCE SOURCE: Agricultural Chemicals abstracts
1 Acute toxicity (Dermal) Not classified - - - - Based on rat LD50 value: >10000mg/kg (Agricultural-Chemicals abstracts), it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Rat LC50 (4 hours) value is >4.1mg/L (Agricultural-Chemicals abstracts). But the category could not be specified only by this data, it cannot be classified since data is insufficient.
2 Skin corrosion/irritation Not classified - - - - Since a skin reaction was not admitted in the skin irritation test using a rabbit (Agricultural-Chemicals abstracts), it was carried out the outside of Category.
3 Serious eye damage/eye irritation Not classified - - - - In the eye irritation tests using a rabbit, the change in the eyes that is applicable to the acceptance criteria of irritation was not acknowledged (Agricultural-Chemicals abstracts). So it was set as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - We classified it as Out Of Category since positive rates was 0% also in both of Maximization test and Buehler test (Source: Agrichemical Abstracts) with the guinea pigs.
5 Germ cell mutagenicity Not classified - - - - There was a negative result in the micronucleus test which used the mouse marrow, an in vivo mutagenicity test using somatic cells (Agricultural-Chemicals abstracts). So it was classified as out of Category.
6 Carcinogenicity Not classified - - - - It was considered as the out of Category. Since although either institutions did not classified about carcinogenicity, the carcinogenicity was not observed in mixed feed medication test in long term using rat (Agricultural-Chemicals abstracts).
7 Reproductive toxicity Not classified - - - - It was considered as outside of Category since in the fecundity and the teratogenicity study (maximum dose of 10000 ppm) of the rat feeding administration test, and in the rabbit teratogenicity study (maximum dose of 1000mg/kg), reproductive toxicity was not observed (all are agricultural-chemicals abstracts).
8 Specific target organ toxicity - Single exposure Not classified - - - - In oral administration tests using rats, mice and dogs, and inhalation exposure and dermal administration tests using rats, since the toxic effect with serious dose exceeding the guidance value range of Category 2 did not have private seals (Agricultural-Chemical abstracts), it was set as the outside of Category.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - Since major toxicity was not observed with the dose which exceeds the guidance value range of Category 2 in the oral study using rats, mice and dogs, either (Agricultural Chemicals abstracts), it was set to out of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 72-hour EC50<=0.5mg/L of algae (Green algae) (Agricultural Chemical Registration Data, 2001).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=3.2(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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