GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Silicic acid, (H4SiO4), tetraethyl ester
CAS：78-10-4
Result：
| ID: | 834 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Flash point: >=23degC and <=60degC |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | It is classified into the UNRTDG class 3. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | UNRTDG Class: 3 |
| 13 | Oxidizing liquids | Not classified | - | - | - | - | UNRTDG Class: 3 |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
| 16 | Corrosive to metals | Not classified | - | - | - | - | UNRTDG Class: 3 |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Not classified because of SPECIES: Rat; ENDPOINT: LD50; VALUE: :6270mg/kg; REFERENCE SOURCE: DFGOT vol.3 (1992) |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on rabbit LD50 value: 6300uL/kg (reduced values = 5859mg/kg) (RTECS, 2006), it was set as the outside of Category. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | There was description about the rat mortality rate in the steam exposure test (DFGOT (vol.3, 1992) and Industrial Hygiene Society advice (1993)). But there was no data of LC50 value, and since Category could not be specified, it cannot be classified due to data insufficiency. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | There was description in DFGOT (vol.3, 1992) about the mortality rate in the mist atmospheric exposure test which used rats. But there was no data of LC50 value, and category could not be specificked. Therefore, it cannot be classified since data is insufficient. |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
There was no concrete case report. But it was set to Category 2 from description that the skin is stimulated in ICSC (J), (1998), HSFS (1999), and SITTIG (4th, 2002). |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
If based on description that the change acknowledged by applying to the eye of the rabbit was recovered within 24 hours (HSDB (2006)), it will be judged that there is no irritation in practice. But based on the deacription that mild irritation was acknowledged by applying to the eye of the rabbit (RTECS (2006)), it was set as Category 2B. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (blood), Category 3 (respiratory tract irritation, narcotic effects) |
|
Danger Warning |
H370: Causes damage to organs (blood) H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
It was set as Category 1 (blood) from description that severe anemia was acknowledged by the concentration of the guidance value range of Category 1 in the inhalation exposure test using the guinea pigs of DFGOT (vol.3, 1992). Moreover, it was set as Category 3 (respiratory irritant, anesthetic actions) from description that the anesthetic actions was admitted in the inhalation exposure tests using a guinea pigs and, respiratory irritant was admitted in the exposure tests to the humans of DFGOT (vol.3, 1992). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (kidney, liver, respiratory system) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (kidney, liver, respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on description that in the inhalation exposure test using the rat of PATTY (4th, 1994), ACGIH (7th, 2001), DFGOT (vol.3, 1992), and Japan Society for Occupational Health Recommendation of Occupational Exposure Limits (1993), the influence on kidney, liver and lungs was observed at the concentration a little exceeding the guidance value range of Category 2, and that renal and intranasal changes were observed within guidance value of Category 2 in the inhalation exposure test using mice by Japan Society for Occupational Health Recommendation of Occupational Exposure Limits (1993), it was classified into Category 2 (the kidney, liver,respiratory systems) |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |