GHS Classification Result

Chemical Name:Ronnel
CAS:299-84-3

Result:
ID: 829
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC (1995))
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though the substance contains P-O bonds as chemical groups with self-reactive properties present.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC, 1995)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC (1995))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Since aqueous solubility is measured (ICSC (1995), Merck (13th, 2001), Howard (1997)), it is judged that it is stable in the water.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - Classification not possible due to lack of data, though containing oxygen bonded to phosphorus.
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
It was set as Category 4 based on LD50= 1492mg/kg calculated from five data of rat LD50 value (ACGIH (2001) and JMPR 130 (1968)).
1 Acute toxicity (Dermal) Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
It was set as Category 4 based on LD50= 1600mg/kg which is the lower value among two data (ACGIH (2001)) of rabbit LD50 values.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description as which hyperemia of the only slight skin was regarded by the examination of the rabbit (ACGIH (2001)), and the description of having felt the irritation for the skin of the human face (HSDB (2005)), it was set as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
There is the statement that although slight sense of discomfort and transient conjunctival irritation were seen in the rabbit , but they were disappeared 48 hours afterward (ACGIH (2001). So it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - We classified it as Out Of Category based on the statement that it was not thought to have a skin sensitizing property in the patch test performed in human body(ACGIH (2001), HSDB (2005)).
5 Germ cell mutagenicity Classification not possible - - - - Since there is no in vivo test result, and multiple indices has not resulted in positive with in vitro examination, it was presupposed that it cannot be classified.
6 Carcinogenicity Not classified - - - - It was considered as the outside of Category based on that it was classified into A4 in ACGIH (ACGIH (2001).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Although there is no statement on maternal toxicity in rat and rabbit test, the fetus with cardiovascular system malformation and those with cerebellum hyperplasia increased in number, and it is observed the effects on the viability F1 and F2 and lacting index (PATTY(5th, 2001) vol.7, JMPR 130 (1968)). Therefore, it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (nervous system)
H335: May cause respiratory irritation (respiratory tract irritation)
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
It was set as Category 2 (nervous systems). based on the statement (ACGIH (2001)) that sweating, closeness, loss of consciousness, vomited, a miosis, muscular spasticities, the excess of salivation, nausea, muscular spasticities, etc. are indicated in humans (ICSC (J) (1995)), and salivary secretion, tremor, diarrhea, the miosis, and increased respiration in a rat by the dose considered to be the guidance value range of Category 2 are indicated. It was set as Category 3 (respiratory irritant) based on statement (HSDB (2005)) that the irritant of the throat for humans.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on statements that inhibition of the cholinesterase activities was observed in dogs at administration of guidance value within the limits of Category 1 (ACGIH (2001), JMPR 130 (1968)), that nausea, debility, blurred visions, etc. were seen in patients with creeping eruption as side effects at the time of medicating (ACGIH and (2001), HSDB (2005)); and that an abdominal cramps, anorexia, a blurred visions, diarrhea, headach, heartburn, malaise, nausea, debility, etc. were observed in humans when medicated (JMPR 130 (1968)), it was classified into Category 1 (nervous systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour LC50=171microg/L of fishes (Cutthroat trout) (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=4.88 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

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