GHS Classification Result

Chemical Name:Phenol, 4,4'-thiobis[2-(1,1-dimethylethyl)-5-methyl]-
CAS:96-69-5

Result:
ID: 827
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 240degC (Lange, 16th, 2005) and a non-pyrophoric substance at a room temperature.
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Category 5 based on SPECIES: Rat; ENDPOINT: LD50; 2345mg/kg; REFERENCE SOURCE: (RTECS 2005)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - No data available
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Classification not possible - - - - There is no data and we could not classify it.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
We classified it as Category 1 based on the enrollment in which the patient who developed the contact skin hazard with the rubber gloves including this substance gave the positive result for the patch test (ACGIH (2001)).
5 Germ cell mutagenicity Classification not possible - - - - Although there is a report of negative results for in vitro Ames' test and chromosomal aberration test (Ministry of Health and Welfare reports (2006) and ACGIH (2001)) since there is no report of in vivo examination, it cannot be classified.
6 Carcinogenicity Not classified - - - - Carcinogenesis was not observed in the study in NTP, and it was A4 in ACGIH. It considered as the outside of Category.
7 Reproductive toxicity Classification not possible - - - - Although there is a description that there is effect on maternal lethality and decrease of infant viablity, but no effect on live fetuses count, fetuses count, weight at newborn and increase infant eright in pregnant mouse administration test (NTPTR435 (1994)), it cannot be classified due to insufficient data.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - There is a test report of a rat but no report of humans. Since diarrhea is only acknowledged out of the guidance value of Category 2, it cannot be classyfied due to insufficient data.
9 Specific target organ toxicity - Repeated exposure Category 2 (intestinal tract, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (intestinal tract, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on a statementwhere within the guidance value of Category 2, influence on an intestinal tract (vacuolation of absorptive epithelial cells and cell infiltration of membrane at cecum and colon, the hyperplasia of the small intestinal wall, etc.), increase in liver weight, and hypertrophy of hepatocyte around lobule were observed (Ministry of Health and Welfare reports (2006)), it was classified into Category 2 (intestines, liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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