GHS Classification Result

Chemical Name:petroleum ether
CAS:

Result:
ID: 819
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - No data available
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (room temperature)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (room temperature)
5 Gases under pressure Not applicable - - - - Liquid (room temperature)
6 Flammable liquids Category 1 Danger H224: Extremely flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Category 1 because of its flash point: -49degC(< 23degC) and initial Boiling point: 30degC(<= 35degC)
7 Flammable solids Not applicable - - - - Liquid (room temperature)
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not classified - - - - Based on that the ignition points is 246 degC (dangerous decibel (the 2nd edition, 1993)) (> 70 degC), it was classified as the outside of Category.
10 Pyrophoric solids Not applicable - - - - Liquid (room temperature)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - No data available
13 Oxidizing liquids Classification not possible - - - - No data available
14 Oxidizing solids Not applicable - - - - Liquid (room temperature)
15 Organic peroxides Classification not possible - - - - UNRTDG No. 1202 Class: 3
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - No data available
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (room temperature)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Failures of corneum are caused by contact for 30 minutes on the human skin. Moreover, it was set as Category 3 by publication that although pentane, hexanes, heptane, and octane which were the composition ingredient of the petroleum ether caused erythema, hyperemia, swelling, and pigmentation to human skin. But when hexanes and heptane were eliminated, the pain decreased in the short time and the discontinuation of exposure recovered unfounded (NIOSH (1997)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
There is the description that petroleum ethers's principal components are pentanes and isohexanes (NIOSH (1977). And there is the description as to n-pentane, though in the eye irritation tests in rabbits, transient conjunctivitis were acknowledged it recovered within 72 hours. So it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - No data available
6 Carcinogenicity Classification not possible - - - - Insufficient data available
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects, Respiratory tract irritation) Warning H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 3 (anesthetic actions, respiratory irritant).based on the statement (NIOSH (1977)) that pentanes and isohexisan are the principal components of petroleum ethers (NIOSH (1977)), and pentanes showed an anesthesia action and respiratory irritant in short time mouse inhalation study.
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It was stated that pentanes and isohexane are as primariy components of petroleum ethers (NIOSH (1997)), that polyneuropathy was occurred in humans exposed to a hexane solvent (16% methylpentane, 20% methyl cyclopentane, and 64% n-hexane) in high concentrations for one month or more (NIOSH (1997)), and that the result of inspection of the laborers exposed to the solvent which consists of pentane and 14% heptane and 5% hexane 80% showed that anorexia, adynamia, dysesthesia, malaise, and bilaterality and symmetry myopathy were indicated(NIOSH (1997)); it was classified into Category 2 (nerve systems)
10 Aspiration hazard Category 1 Danger H304: May be fatal if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ...
We classified it as Category 1 based on the fact that the petroleum ether contains pentane and iso hexane as the principal components (NIOSH (1997)), and the pentane is a hydrocarbon and its dynamic viscosity is 0.374mm 2/s at 20 degrees C (calculated from the viscosity 0.234 mPs-s at 20 degrees C, and the density of 0.62624g/cm3).

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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