GHS Classification Result

Chemical Name：polybrominated biphenyl
CAS：

Result：
ID: 803
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-flammable (HSDB (2003))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not classified because of "Not flammable" (HSDB, 2003)
11 Self-heating substances and mixtures Not classified - - - - Not classified because of non-flammable (HSDB, 2003)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - There are 21500, 2000, >5000, >20000 mg/kg (EHC 152 (1994)), >2000 mg/kg (IARC 41 (1986)) and 17000 mg/kg (PATTY (5th, 2001)) as rat LD50, and it was set as the outside of Category based on these data.
1 Acute toxicity （Dermal） Not classified - - - - There are rabbit LD50s: 5000, 5000, > 10000, >10000, >8000mg/kg (EHC 152 (1994)), and there is rat LD50 >5000mg/kg (EHC 152 (1994)). It was set as the outside of Category based on these data.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on the report that there is no mortality (EHC 152 (1994)) by 71 and 200mg/L (1h) (converted value for 4 hours are 17.8 and 50mg/L, respectively) in rats, it was set as the outside of Category.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. With a single or two-week repetition application, slight erythemas and edemas were observed on rabbit or guinea pig skin (EHC 152 (1994), ATSDR (2004)), and skin reactions was not observed depending on test conditions (ATSDR (2004)), therefore, it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on what by applying to the eyes of the rabbit, slight irritations, temporary redness, and edema corneal are acknowledged (ATSDR (2004), it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - We classified it as Out Of Category since sensitizing property is not acknowledged in the skin sensitivity test using guinea pigs (EHC 152 (1994)).
5 Germ cell mutagenicity Not classified - - - - Based on the descriptions (EHC 152 (1994), NTP DB (2006)) that it gave negative for all of the in vivo mutagenicity tests (the chromosomal aberration test using the spermatogenic cells and marrow cells of the rat, the chromosomal aberration test using the mouse marrow cells, and micronucleus examination using the marrow cells of the mouse) using the germ cells and somatic cells, we classified it as Out Of Category.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as 2 based on being classified into 2B according to IARC (1987).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		A cleft palate, a diaphragmatic hernia, a cerebral hernia and malformation of hydronephrosis to fetus in rat or mouse organogenetic period administration test are reported (EHC 152 (1994)), moreover, in pregnant period and/or lacting period administration test, lowering the rates of implantation, increasing the embryo resorptions, increasing the a fetal death, and increasing the weaning infant mortality are also described (EHC 152 (1994), ATSDR (2004)). However, since description was not seen about the general toxicity to parent, it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (liver) Danger H370: Causes damage to organs (liver) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is reported that a single-time oral administration of 10 - 13.3mg/kg of 3,3',4,4'-tetrabrominated biphenyl or 3,3',4,4',5,5'-hexabrominated biphenyl to a rat causes effects which mainly include diffuse cytomegaly and cytoplasmic vacuolation accompanied by sinusoidal obstruction in liver (EHC 152 (1994)). Therefore we classified it as Category 1 (liver). In addition, oral administration of FireMaster FF-1 showed the similar effects on liver in rats (PATTY (5th, 2001)).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, thyroid, kidney, nervous system, skin) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, thyroid, kidney, nervous system, skin) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		To rats or mice, in repeated oral administrations of the dosage below 10 mg/kg/day (as 90-day medication), liver hypertrophy accompanied by an elevations of liver enzymes, histological changesuch as vacuolization and hepatocyte hypertrophy [finding of liver] (EHC 152 (1994)), histological change such as hyperplasia accompanied by a thyroid hormones (T3, T4) decrease etc. [thyroid findings] (EHC 152(1994), ATSDR (2004)), chronic renal impairment [kidney findings] (EHC 152 (1994), and a locomotor activity decrease, decrease of the grip and the extensor reaction of front limb and hind limb (NTP TR398 (1993)) [nervous systems] are observed. On the other hand, huge and various surveillance study concerning the health of the humans are performed after the pollution accident in Michigan, U.S. Then, an evelation of liver enzymes, such as GPT and GOT, liver hypertrophy [finding of liver] (ATSDR (2004)), a hypothyroidism [thyroid findings] (EHC 152 (1994)), neurological symptoms, such as fatigue, concentration-lacking and depression, muscle weakness [nervous system findings] (EHC 152 (1994), ATSDR (2004)), and as systemic symptoms, skin condition such as acne, release, exfoliation, and erythema [skin observation] (ATSDR (2004)) are reported. It was classified into Category 1 (liver,thyroid,kidney,nervous systems,skin) based on the above informations.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations

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