Chemical Name:dimethylnitrosoamine
CAS:62-75-9
ID: | 800 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not classified | - | - | - | - | Containing nitro groups with its oxygen balance<-200 (-216), (C2H6N2O + 5O2 -> 2CO2 + 3H2O + 2NO2; oxygen balance=-1600 * 10/74 = -216) |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 4 | - | Warning | H227: Combustible liquid |
P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Category 4 because of its flash point: 61degC(ICSC, 2001) |
7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | No data available |
9 | Pyrophoric liquids | Classification not possible | - | - | - | - | No data available |
10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Classification not possible | - | - | - | - | No data available |
14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable | - | - | - | - | There are no chemical groups associated with peroxide present in the molecule. |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 2 | Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
It was set as Category 2 based on rat oral acute toxicty LD50= 27mg/kg (statistical process value). | |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 | Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
It was classified as Category 1 based on rat acute inhalation toxicities LC50 = 78ppm (ACGIH (2001), PATTY, 5th (2001)). | |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | Based on the report of irritativity on human skin (ICSC(2001); Patty, 5th (2001)) and the statement of "not significantly irritating to the skin" (Patty, 5th (2001)), it was classified as Category 3. |
3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on that irritation is reported to the man's eye (ICSC(2001); PATTY, 5th (2001)), and that there is the statement of "not significantly irritating to the eyes" (Patty, 5th (2001), it was set as Category 2B. |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | About respiratory sensitization and skin sensitization, there is no data for both of them. |
4 | Skin sensitization | Classification not possible | - | - | - | - | About respiratory sensitization and skin sensitization, there is no data for both of them. |
5 | Germ cell mutagenicity | Category 1B | Danger | H340: May cause genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the fact that it gave positive (CICAD (2002)) for the mouse productive cells micronucleus examination which was an in vivo mutagenicity test using the productive cells, we classified it as Category 1B. In addition, alkylation was also acknowledged in human hepatocyte DNA (ATSDR (1989)). | |
6 | Carcinogenicity | Category 1B | Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
The existing classification is carried out as IARC: 2A, NTP: R, and EU Carc.: Cat.2. It was set as category 1B. | |
7 | Reproductive toxicity | Category 2 | Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There is a report of induction of stillbirth and newborn child death in mouse oral administration at 0.02mg/kg/day (in drinking water) and no information about maternal toxicity (ATSDR (1989)). It was classified into Category 2 based on the above. | |
8 | Specific target organ toxicity - Single exposure | Category 1 (liver), Category 3 (respiratory tract irritation) |
Danger Warning |
H370: Causes damage to organs (liver) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
It is reported that exposure to humans causes adverse effects including jaundice, ascites, prolonged vomiting and abdominal spasm (ATSDR (1989)). Therefore we classified it into Category 1 (liver). And animal data also suggest the toxicity to liver. In addition, respiratory irritation was reported (ICSC (2001)). So we classified it as Category 3 (respiratory irritant). | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the statement that by repetitive oral administration with the dose equivalent to the guidance value of Category 1 to rats and rabbits, vacuolization of hepatic cells and fibrosis of liver are observed (ATSDR (1989)), and that an liver dysfunction and liver cirrhosis may be occuered in humans (ICSC (2001)), it was classified into Category 1 (liver). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Not classified | - | - | - | - | It carried out the outside of Category from 96-hour LC50=280-445mg/L of Crustacea (Amphipod) (CICAD38, 2002). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified | - | - | - | - | Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website (in Japanese Only) |