GHS Classification Result

Chemical Name:Dimethyl disulfide
CAS:624-92-0

Result:
ID: 799
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
It was classified as Category 2 (the acceptance criteria of GHS: flash point being less than 23 degC, and initial boiling point being more than 35 degC) based on 15 degC of flash point and 109.74 degC of initial boiling point.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: >300degC (ICSC, 2004)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Not classified because of UNRTDG Class: 3
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
SPECIES: Rat ENDPOINT: LD50 VALUE: 190 mg/kg REFERENCE SOURCE: PATTY (5th, 2001) vol.7
1 Acute toxicity (Dermal) Not classified - - - - It was set as the outside of Category based on the report that there is no death at rabbit LD50 >2000mg/kg (IUCLID (2000)) (PATTY(5th, 2001) vol.7).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Since the saturated vapor pressure concentration of this product is 37871ppm, it is thought that all inhalation tests were done with vapor. It was classified as Category 3 based on the converted value for 4 hour exposure from rat LC50 = 805ppm (PATTY(5th, 2001) vol.7) .
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
It was classified as Category 2 based on the description that moderate to severe erythema and edema were observed on rabbits (ECETOC TR66 (1995), PATTY(5th, 2001) vol.7).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on the statement that in the rabbit the eye irritations such as conjunctival injections, edema, and eye irritations are seen (PATTY(5th, 2001) vol.7, IUCLID (2000)), and recovered completely in 4 - 7 days (PATTY(5th, 2001) vol.7), it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - We classified it as Out Of Category based on two or more publications (PATTY(5th, 2001) vol.7, IUCLID (2000)) which describes that skin sensitization was not acknowledged in sensitization test with guinea pigs.
5 Germ cell mutagenicity Not classified - - - - Based on the fact (PATTY(5th, 2001) vol.7) that we found no results of human over generation epidemiology, human over genetration mutagenicity test, and the human in vivo productive cell mutagenicity test, and we found the negative result for the in vivo micronucleus test with the mouse. So we classified it as Out Of Category.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was classified into category 2 based on that growth delay and teratogenicity of a child were observed in the dose (50 ppm) causing toxicity to parental animals (PATTY(5th, 2001) vol.7) .
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, olfactory organ), Category 2 (blood) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, olfactory organ)
H373: May cause damage to organs through prolonged or repeated exposure (blood)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It was classified into Category 1 (respiratory organs, olfactus organ) based on the statement in rat of the exposure dosage of guidance value within the limits of Category 1, dysplasia of respiratory mucosa in a nasal cavity, withering and cell deletion of olfactory sensory epitheliums were observed (PATTY(5th, 2001) vol.7, IUCLID (2000)). At the dosage in the guidance value range of Category 2 (0.2-1.0 mg/L), the reduction of erythrocyte count, the hemoglobin concentration decrease, and the decrease of a hematocrit value (PCV value) were seen in the rat (IUCLID (2000)). Although at a higer dose, the similar changes were observed also with the rabbit, and it was accompanied by increased reticulocyte counts and increased hematopoietic (PATTY(5th, 2001) vol.7). It is presumed that cause of the effect on erythropoiesis and heme synthesis is inhibition to uptake of Fe to reticuloendothelial system in humans (IUCLID (2000)). Since the above, it is thought that it was the anemia by effects to blood and was classified into Category 2 (blood).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 96-hour LC50=1.1mg/L of fishes (Oryzias latipes) (MOE eco-toxicity tests of chemicals, 1998).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 2, since acute toxicity was Category 2, and not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though supposed less bio-accumulative (log Kow=1.77(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

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