GHS Classification Result

Chemical Name：Dimethyl carbamyl chloride
CAS：79-44-7

Result：
ID: 798
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Category 3 because of its flash point: between 60 and 90 degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - The ignition points is 410 degC, and it is thought that it does not ignite in room temperatures.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available on a corrosive rate to metals

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		There were two data of rat LD50: 1170mg/kg (ACGIH (2001)) and 1000mg/kg (RTECS (2004)). Both were in 300 to 2000 mg/kg, and they were set as Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - There is no data of acute dermal toxicity, so it cannot be classified.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is data of rat steam inhalation LC50 (6 hours): 180ppm (RTECS (2005)), and it is 220.5ppm if it is converted for 4 hours. Since it fall into the range of 100 - 500ppm, it was classified as Category 2.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - Since data from animal studies cannot be found, it cannot be classified. Since there is description that the skin of rodent is stimulated (IARC 71 (1999)) and R38 is designated in EU, it is supposed to be Category 2 or 3.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Since there is the desceiption that the eye of the rabbit is stimulated in IARC 71(1999), it was referred to as "Category 2". It is indicated that there is strong tearing property in HSDB (2005). Since there is no data of recover days, subdividing into 2A and 2B is not possible.
4 Respiratory sensitization Classification not possible - - - - There is no information and we could not classify it.
4 Skin sensitization Not classified - - - - Although we were not able to find out the experimental data for skin sensitization, we classified it to be"Out Of Category" since IARC 71 (1999) describes that "the proof of sensitizing property was not able to be found out with guinea pigs."
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		We found the positive findings of two affairs for In vivo micronucleus tests of the mouse (IARC 71 (1999)), however, there were no data for the over generation mutagenicity test and the In vivo productive cell mutagenicity test, we classified it as "Category 2." Many positive findings were obtained in the In vitro tests.
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is no anecdotal report about humans, but positive finding is obtained by many animal studies (ACGIH (2001), IARC 71 (1999).). It was set as "Category 1B" from the assessment of 2A of IARC, and A2 of ACGIH, and the carcinogenic category 2 of EU.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Rat inhalation experiment results damages to nasal mucosa, throat and lungs (IARC 71 (1999)). But we does not classify it into Category 1 and 2 because there is no description about exposure concentration to be compared with the guidance value. HSFS (1998) has the descriptions of "respiratory irritation" and "headache, nausea and vomiting.". We classified it as "Category 3 (respiratory irritation)."
9 Specific target organ toxicity - Repeated exposure Category 1 (liver), Category 2 (respiratory system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (liver)
H373: May cause damage to organs through prolonged or repeated exposure (respiratory system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since IARC 71 (1999) had description of liver disorders, it was classified into "Category 1 (liver)." In HSFS (1998), the warning of lungs and bronchitis is indicated, too. Despite the information on the inhalation test (15 days) of a rat, there was no effect description except for deaths (ACGIH (2001)). Therefore, Category 2 (respiratory systems) was added.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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