GHS Classification Result

Chemical Name：N,N-Dimethylaniline
CAS：121-69-7

Result：
ID: 796
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: 62degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - The ignition points is 371 degC, and it is thought that it does not ignite in room temperatures.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available on corrosion to metals

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Mean 1088 mg/kg was obtained from five data (ACGIH (2001), DFGOT vol.3 (1991), RTECS (2005), IUCLID (2000)) covering rat oral LD50: 951 to 1410 mg/kg. Since it was in the range of 300 to 2000 mg/kg, it was set as Category 4.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		There are rabbit dermal absorption acute LD50s = 1770mg/kg 8ACGIH (2001) and 1692mg/kg (DFGOT vol.3 (1991)). All were in the range of 1000 - 2000 mg/kg, it was set as Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - There is no data of LC50 with steam inhalation, and it cannot be classified. There is a rat lower fatality report of 50ppm/4H (ACGIH (2001)), and it is thought that toxicity is high.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		There was no 50% lethal dose data in mist inhalation. But there is information that 40% died within four days from inhalation exposure of mist 1.88mg/L for 4 hours (DFGOT vol.3 (1991)), and it is thought that LC50 goes into 1.0 - 5.0mg/L.. It was set as Category 4.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. There is a report on human patch test that there was no irritation (IUCLID (2000)). But it was classified as Category 3 because there is a statement of "MILD" with skin application test on rabbits (RTECS (2005)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Since there is the report of "MODERATE" in the administration test to the eyes of the rabbit, it was set as "Category 2A".
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - It gave a weak positive result in the in vivo study report (IUCLID (2000)). Although the in vitro results were described in ACGIH (2001), DFGOT vol.3 (1991), and IARC 57 (1993), that it gave negative for bacteria and it gave positive for mammals cultured cells. However, these articles did not state about the In vivo examination, and these have not carried out overall rating, either
6 Carcinogenicity Not classified - - - - There is a report that the papillomatosis at the front stomach of male mouse and the growth of sarcoma at spleen of male rat were seen in the carcinogenesis bioassay which was carried out by NTP. It was judged with "2B" by Japanese industrial hygene academic Society acceptable limit recommendations for Hygiene and with "3" by the EU category. But IARC is set to "3" and ACGIH to "A4." According to the opinion of a specialist, it carried out "Category Outside."
7 Reproductive toxicity Classification not possible - - - - The bad influence to the newborn infant was not observed in two administration experiments to the pregnant female mouse (ACGIH (2001), DFGOT vol.3 (1991)). However, there is no test report about the reproductive potential of a male rat, and data is insufficient to make it the outside of category syntheticly.
8 Specific target organ toxicity - Single exposure Category 1 (blood system, nervous system), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (blood system, nervous system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Symptoms accompanied by methemoglobin production are found in humans (ICSC (1998)) as well as in dogs and rats within the guidance value to Category 1 (ACGIH (2001), DFGOT vol.3 (1991)). In addition, asneuropathy and anesthetic actions are observed in humans (ICSC (1998), ACGIH (2001)). Therefore we classified it into "Category 1 (blood system, nervous system) and Category 3 (anesthetic action)."
9 Specific target organ toxicity - Repeated exposure Category 1 (blood, spleen, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (blood, spleen, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on that in repeated exposure experiments of rats with exposure-dose equivalent to the guidance value of Cattegory 1, the affect on blood (methemoglobinemia, anemia), a spleen, and liver (no detailed statements) is observed (ACGIH (2001), RTECS (2005), IUCLID (2000)), it was classified into "Category 1 (blood, spleen,liver)".
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data on chemical pneumonia

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour EC50=5mg/L of Crustacea (Daphnia magna) (IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and not rapidly degrading (BOD: 1.9% (existing chemical safety inspections data)), though less bio-accumulative (BCF=13.6 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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