GHS Classification Result

Chemical Name：Acetamide, N,N-dimethyl-
CAS：127-19-5

Result：
ID: 795
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Category 4 because of its flash point: 63degC (SIDS, 2001)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - The ignition points is 400 degC and does not ignite spontaneously in normal temperatures.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Category 5 based on SPECIES: Rat; VALUE: 4263mg/kg; REFERENCE SOURCE: IUCLID (2000)
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. There is rabbit trial report (IUCLID (2000)), and all are in the range of 2100 - 3600 mg/kg. So it is classified into Category 5.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is rat test (IUCLID (2000)), and the calculated value converted into ppm of 4 hour inhalation was about 1100ppm. So it was classified as Category 3.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Although it is considered to have no stimulativeness on humans (SIDS (2001)), results of having mild irritation (RTECS (2004)) or no stimulativeness (SIDS (2001)) are obtained with rabbits. The results on guinea pigs is severe irritation, and on mice is slight to no stimulativeness depending on doses (SIDS (2001)). These data is synthesized, and it was judged to have mild irritation. So it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		It is considered as "slightly irritating" in humans, but indicating "mild" and reversible irritation in the almost tests using rabbits, it is classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - We have no data and we could not classify it.
4 Skin sensitization Not classified - - - - We classified it as Out Of Category according to the description that it has no sensitizing property for human and guinea pigs (SIDS (2001), PATTY (2001)).
5 Germ cell mutagenicity Not classified - - - - Increase of the chromosomal aberrations was not acknowledged in the survey for the workers (SIDS (2001)). Moreover, because we found negative data in some in vivo examinations, such as the dominant lethality examination using the rat and the mouse, and the chromosomal aberration test of rat marrow (SIDS (2001)), we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - There is a report that carcinogenic is not seen in the tests using rats, hamsters, and mice (SIDS (2001)). Moreover, since ACGIH has classified into A4 (Not Classifiable as a Human Calcinogen), it carries out the outside of Category.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is classified into category 1B since that abnormalities are observed of fetal organ and skeletal formation in the rabbit study in the pregnant mother administered orally through drinking waters or nasogastric tubes (SIDS (2001), ACGIH (2001)), and abnormalities are obaserved of fetal organ and skeletal formation as same in pregnant maternal inhalation exposure (SIDS (2001)), moreover, EU has classified into the reproduction Category 2 (damage may be occur to a fetus).
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a report that it has an effect on liver within the limits of the inhalation exposure guidance value to Category 1 in mammalians whose animal species is not specified (RTECS (2004)). However, the data is inadequate as a reason for classification. Classified into Category 3 (anesthetic action) because it is regarded as inducing giddiness, lethargy and frailty in humans (ACGIH (2001)).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on that dysfunction of the liver is observed in the worker engaged in the workplace treating DMA for a long-term period (ACGIH (2001)), hypertrophy liver is observed in the inhalation exposure test using a rat within the range of the guidance value of Category 2 (SIDS (2001), ACGIH (2001)), and the effects on the liver is observed in the inhalation study using a mouse within the range of the guidance value of Category 2 (PATTY (2004)), experience with humans is considerd seriously and it is classified into Category 1 (target organ: liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 48-hour EC50>500mg/L of Crustacea (Daphnia magna) (SIDS, 2004).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information