GHS Classification Result

Chemical Name：Benzoyl peroxide
CAS：94-36-0

Result：
ID: 794
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - UNRTDG No. 3102, 3104, 3106, 3107, 3108, 3109, Class: 5.2
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Not classified because of UNRTDG Class5.2(UN No.3102, 3104, 3106, 3107, 3108, 3109)
8 Self-reactive substances and mixtures Not applicable - - - - Classified in organic peroxidies
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 80degC (ICSC (J), 2002)
11 Self-heating substances and mixtures Classification not possible - - - - Since the melting points are 103 degC - 105 degC (ICSCJ, 2002) and 140 degC or less, the test specified by GHS is inapplicable.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and the oxygen is chemically bonded only to carbon (but not to other elements).
15 Organic peroxides Type B, Type C, Type D, Type E, Type F Danger H241: Heating may cause a fire or explosion P411+P235: Store at temperatures not exceeding ... degC/... degF. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P234: Keep only in original container.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P410: Protect from sunlight.
P420: Store away from other materials.
P501: Dispose of contents/container to ... 		It is subdivided to type B to F depending on the content in products or etc. (Refer to the paragraph of the UNRTDG)
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - SPECIES: Rat ENDPOINT: LD50 VALUE: 7710 mg/kg REFERENCE SOURCE: SIDS (2002)
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Not classified because of "SPECIES: Rat; ENDPOINT: LC50>19.0mg/L" (SIDS,2002)
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. There is data of "slight irritation" or "having no irritation" and SIDS (2002) concluded "it is a very mild skin irritation substance", therefore, it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		The irritation is acknowledged in rabbits 24,48 and 72 hours after the exposures (SIDS, (2002), however the degree of irritation differs depending on the tests or the test methods. Therefore, it was set as Category 2A-2B.
4 Respiratory sensitization Classification not possible - - - - Since we have no data, we could not classify.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Skin sensitization is acknowledged in the human maximization test results and in the epidemiological research for occupational exposure (SIDS, 2002), moreover, it is published as a surface sensitization in the Japanese Society of Occupational Allergy list. Therefore, we classified it as Category 1.
5 Germ cell mutagenicity Not classified - - - - Since it gave negative (SIDS, 2002) in the dominant lethality tests by mice and micronucleus tests using the mouse erythrocytes, we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - Since it had classified into the class 3 according to IARC, it carried out the outside of Category.
7 Reproductive toxicity Not classified - - - - It is observed that reduction of the weight and degenerative effects of male rats genitalia. These should be considered as organ damage, of general toxicity caused in repeated administration in extensive dose (1000mg/kg/day), occured in the male genitalia, and no change has been observed in the items related to reproductive toxicity (mating rate and pregnancy rate in female rats). Moreover, although there are cases of high birth rate of runts and significant reduction in weight gain of offsprings under condition of no maternal toxicity (SIDS,2002), their toxicological significance would be low. Therefore, it was placed out of classification.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Classified as Category 3 (respiratory irritant), based on the information that it has irritation to nose and throat in humans (ACGIH, 2001).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour EC50=0.07mg/L of Crustacea (Daphnia magna) (SIDS, 2004).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (BOD: 84% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=3.46 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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