GHS Classification Result

Chemical Name：1,2-Dinitrobenzene
CAS：528-29-0

Result：
ID: 790
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Not classified in UNRTDG Class: 1, though containing nitro groups.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data (by test methods of UN) available
8 Self-reactive substances and mixtures Classification not possible - - - - The grouping in connection with autoreactive is not included. Although the grouping in connection with explosibility is included, there is no data of laboratory tests and it cannot be classified. (It is not contained in the U.N. number 3221-3241, and is not the banned substances for carriage, either. Type G is presumed.)
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 150degC. Non-pyrophoric at a room temperature.
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - Containing no halogen. Not classified in UNRTDG Class: 5.1, though containing oxygen bonded to nitrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - There is no data and it cannot be classified. (LD50 value of dinitro derivatives of benzene has a statement of 5 to 60 mg/kg.)
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - There is no data, and it cannot be classified. (As vapor pressureis low, inhalation exposure is with mist or particulate)
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was classified as Category 3 from the statement that it might stimulate human skin (HSDB (2005)).
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		It was considered as Category 2A-B from the statement which stimulates an eye to humans (ICSC (J), (2002), HSDB (2005)). (In the case that subdividing for the indications, etc. are necessary, it is more desirable to be set as Category 2A from the viewpoint of safety.)
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Although there was in vitro Ames test report, there was no in vivo report, therefore we could not classify it.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data and reports
7 Reproductive toxicity Classification not possible - - - - It cannot be classified due to insufficient data, although it was described that it does not participate in testicular injury ( PATTY (5th, 2001).
8 Specific target organ toxicity - Single exposure Category 1 (blood), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (blood)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Classified into Category 1 (blood). Based on the description that its exposure (including dermal exposure) induces methemoglobinemia accompanied, and headache, cyanosis, exhaustion, distraction, palpitation, nausea, vomiting, coma, etc. (ACGIH and (2001), PATTY (5th, 2001), HSDB (2005), SITTIG (47th, 2002)). And iset nto Category 3 (respiratory irritant) based on the description that it stimulates an airway. (ICSC (J) (2002)).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, blood, nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, blood, nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the statement that liver disorders, anemia, and methemoglobinemia are occured by repeated exposure (ACGIH and (2001),ICSC (J)(2001),and HSDB (2005)), it was classified into Category 1 (liver, blood). Based on the statement that nervous systems are affected and occure visual disorder (ACGIH (2001), ICSC (J), (2001)), and that paresthesia on hand and foot by the obstacle of a peripheral nerve are occured (HSDB (2005)), it was classified into Category 1 (nervous system)
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=600microg/L of fishes (Fathead minnows) (AQUIRE, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 0% (HSDB, 2004)), though supposed less bioaccumulative (log Kow=1.69(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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