GHS Classification Result

Chemical Name:O,O-dimethyl-4-oxobenzotriazin-3-ylmethyl phosphorodithioate
CAS:86-50-0

Result:
ID: 786
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - No data available
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite (HSDB (2005)).
11 Self-heating substances and mixtures Classification not possible - - - - Since the melting points are 73 - 74 degC (ICSC (1998), Merck (13th, 2001)), and 140 degC or less, test for which it was suitable has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Not react with water. (Weiss, 2nd, 1985)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - There are no chemical groups associated with peroxide present in the molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substance are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
They were classified into Category 2 based on the value of LD50=10.87 mg/kg obtained by statistics calculation from 32 data of rat oral LD50 value (JMPR 818 (1991), ACGIH (2002), JMPR 111 (1968), PD No.59 (1985), and EHC 63 (1986)).
1 Acute toxicity (Dermal) Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was classified into Category 2 based on the value of LD50 = 93.77mg/kg obtained by statistics calculation of ten data (JMPR 818 (1991), ACGIH (2002), PD No.59 (1985)) of rat percutaneous LD50 values.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on level LC50 = 0.126mg/L obtained by statistics calculation of six data of rat inhalation LC50 (4hr) level (PATTY (5th, 2001), JMPR 818 (1991), ACGIH (2002)), it was classified into category 2.
2 Skin corrosion/irritation Not classified - - - - Since irritation is not caused in rabbit test(ACGIH (2002), JMPR 818 (1991)), it classified as out of Category.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on the statement that "Caused no significant reaction"(JMPR 818 (1991), and "slightly irritating" (IUCLID (2000) in the rabbit test, it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
We classified it as Category 1 since it had induced skin sensitization (JMPR 818 (1991)) for two kinds of skin sensitivity tests (Magnusson and Kligman maximization test and Buehler Patch test).
5 Germ cell mutagenicity Not classified - - - - Based on the negative results (ACGIH (2002), JMPR 255 (1973), and JMPR 818 (1991)) for the in vivo mouse dominant lethality examination (over generation mutagenicity test) and the in vivo mouse micronucleus examination (somatic mutagenicity test), we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - It is classified into A4 according to GCGIH. Based on that sufficient evidence of carcinogenic is not acquired in the 80-week and two-year tests using rats and mice (NTP TR/69 (1978), ACGIH (2002)), it was classified out of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was classified into category 2 based on the statement that increase lethality pre/post implantation and decrease of fetal viability were observed with dose of the level causing a decreased cholinesterase activities in maternal in pregnant rabbit administration (ACGIH (2002)), that decrease of offspring viability is observed in rat one- and two-generation administration test with dose of the level occuring mortality and cholinesterase inhibition to parental animals (ACGIH (2002)) and that decline of child viability till weaning on the level causing maternal mortality in 3 generations of mice study (JMPR 111 (1968)) .
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It classified into Category 1 (nervous systems). Based on the cholinesterase prevention and cholinergic action in rat oral examination (PATTY (5th, 2001)), and the report of the condition under the nerve influence in humans (ACGIH (2002)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on that in the study using a rat, a mouse, and a dog within the limits of the guidance value dosage of Category 1, the influence simptom to nervous systems, such as cholinergic signs, and cholinesterase inhibition were observed (ACGIH and (2002), JMPR 111 (1968)), and cholinesterase inhibition being observed in humans (ACGIH (2002), JMPR 255 (1973), PD No.59 (1985)), it was classified into Category 1 (nervous systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour LC50=0.00029mg/L of Crustacea (Mysid shrimp) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=2.75(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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