GHS Classification Result

Chemical Name：Dicyclopentadiene
CAS：77-73-6

Result：
ID: 783
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Category 3 （Industrial products） Warning H226: Flammable liquid and vapour (Industrial products) P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Category 1 because of its flash point: :23degC - 60degC
7 Flammable solids Category 1 Danger H228: Flammable solids P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Flash point: 32degC
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified （Industrial products） - - - - There is information that the ignition points is 503 degC, and it can be considered that it does not ignite in room temperatures.
10 Pyrophoric solids Not classified - - - - Flash point: 503degC and considered as a non-pyrophoric substance at a room temperature.
11 Self-heating substances and mixtures Classification not possible - - - - It is 33 degC of melting points, and since it liquefies in test conditions of the provision, it cannot examine.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable （Industrial products） - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - Non-corrosive to metals (HSDB, 2005)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		The statistical calculation of 5 data (ECETOC JACC 19 (1991)) distributed from 346.5 to 590 mg/kg as rat oral LD50 was done and the mean value of 373.6mg/kg was obtained. So it was set as Category 4.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Although three data (ECETOC JACC 19 (1991)) distributed 4380 - 6600 mg/kg was found out as rabbit dermal LD50, it was set as "Category 5" from the lowest data of 4380mg/kg.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since the mean of 422ppm (2.28mg/L) was obtained with the statistical work of the four data for rat inhalation LC50 distributed 372 - 660ppm (ECETOC JACC 19 (1991)), it was classified as Category 2.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was classified as "Category 2" since it was Moderate in the application test on rabbit skin (ECETOC JACC 19 (1991)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		The result of the dose experiment to the eyes of a rabbit was mild (ECETOC JACC 19 (1991)). But R36 is applied in EU. Since SIDS (1998) was also set to irritant to eyes, it was set as "Category 2B."
4 Respiratory sensitization Classification not possible - - - - There was no information and we could not classify it.
4 Skin sensitization Not classified - - - - There were two experiment results with guinea pigs, both of which were negative (Source: DFGOT vol.6 (1993) and ECETOC JACC 19 (1991)), so we classified them to be "Out Of Category."
5 Germ cell mutagenicity Classification not possible - - - - Since there were no in vivo experimental results, we could not classify it. There were five in vitro experiment reports and all of them were negative.
6 Carcinogenicity Classification not possible - - - - Since there is no judgment of classification organizations, it cannot be classified. In two caces of rat test reporting, it is judged with negativity (DFGOT vol.6 (1993), ECETOC JACC 19 (1991)).
7 Reproductive toxicity Not classified - - - - It was considered as "out of category "since it had no influence in the feeding administration experiments to pregnant female (ECETOC JACC 19 (1991)), the intragastric administration experiment to the male and female including delivery periods (Ministry of Health and Welfare reports (2006)), and a three generation feeding administration experiments (ECETOC JACC 19 (1991)).
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, liver, kidney), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (respiratory system, liver, kidney)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		There are the effects on the respiratory systems, kidney, liver and paralysis of the extremities are reported by rat inhalation exposure equivalent to the guidance value of Category 1. And anesthesia conditions is regarded by oral treatment to mink (DFGOT vol.6 (1993)). So it is classified into "Category 1 (the respiratory system, liver, kidney), Category 3 (anesthetic actions)".
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney), Category 2 (circulatory system, liver, lung) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (kidney)
H373: May cause damage to organs through prolonged or repeated exposure (circulatory system, liver, lung) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In rat inhalation exposure test, the influence on the kidney within the guidance value of Category 1 is reported (ECETOC JACC 19 (1991)), and the influence on lungs is further reported within the guidance value of Category 2 (ACGIH (2001)). Moreover, in the rat oral administration within the guidance value of Category 2, since the influence to the circulatory organ and liver (Ministry of Health and Welfare reports (2006)) was observed, it was classified into "Category 1 (kidney), Category 2 (cardiovascular,liver,lung)."
10 Aspiration hazard Category 1 Danger H304: May be fatal if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although it is a polycyclic hydrocarbon corresponded by dynamic viscosity, the industrial products contain monocyclic substance (cyclopentadiene) a lot. We classified it as "Category 1."

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96-hour LC50=4.3mg/L of fishes (Oryzias latipes) (SIDS, 2002).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bio-accumulative (BCF=384 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information