GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：osmium tetraoxide
CAS：20816-12-0
Result：
| ID: | 780 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not classified | - | - | - | - | Not an explosive substance, though containing metal- oxygen (Os-O) bonds. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | Non-combustible substance |
| 8 | Self-reactive substances and mixtures | Not classified | - | - | - | - | Although it has bond of metals oxygen (Os-O), it is a class 6.1 in the UN classification. (It is not a class 4.2 (spontaneous combustibility)). |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Non-combustible |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to solid (melting point <= 140degC) substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to wate (the water solubility is obtained) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not classified | - | - | - | - | Not classified in UNRTDG Class: 5.1 though it is an oxidizing agent. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available on corrosion to metals |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
SPECIES: Mouse ENDPOINT: LD50 VALUE: 162 mg/g REFERENCE SOURCE: PATTY(5th, 2001) |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 1 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
It was classified as Category 1 with data of rat LC50: 40ppm (ACGIH (2001), PATTY (5th, 2001)). |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 1A-1C |
|
Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
It was classified as Category 1A-1C based on the information that it has corrosive effects and caused serious dermatitis and blister on human cases(ACGIH (2001)) and (PATTY (5th, 2001)). |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Since it was Category 1A-1C on the skin, and severe irritations are indicated in the human cases and also in the animals tests (ACGIH(2001),(PATTY(5th, 2001), it was set as Category 1. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Since there was no data of respiratory sensitization and skin sensitization, we could not classify about them. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Since there was no data of respiratory sensitization and skin sensitization, we could not classify about them. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | It gave positive by DNA repair test for the in vitro data (PATTY (5th, 2001)), however, there was no in vivo data. Therefore we could not classify it. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system, liver, kidney, adrenal gland, spleen) |
|
Danger | H370: Causes damage to organs (respiratory system, liver, kidney, adrenal gland, spleen) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Bronchitis, pulmonary edemas, and the denaturation pathological change of liver are seen in human cases (PATTY (5th, 2001)). So it is classified into Category 1 (respiratory systems, liver). Moreover, by the exposure test of the rabbit, although it was mainly seen in lungs in 125mg (24 - 28 h), in addition degeneration and hyperaemia was seen in liver, kidney, spleen, and adrenal gland. So it is classified into Category 1 (kidney, spleen, adrenal). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system), Category 2 (kidney, liver, adrenal gland, spleen, hematopoietic system) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) H373: May cause damage to organs through prolonged or repeated exposure (kidney, liver, adrenal gland, spleen, hematopoietic system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Pulmonary edema is observed in the human case (ACGIH (2001)). In the animal studies, bronchial compression is observed in 50mg/kg (45-60 days) dose to the rabbit (PATTY (5th, 2001)) and it was classified into Category 1 (respiratory systems) because of above results. Moreover, since prostration and denatures of liver, the sclerosis of a spleen, and the fatty degeneration of the kidney and the adrenal gland in 50mg/kg (45-60 days) dose to a rabbit, and chronic anemia according to initial superactivity of marrow in 50mg/kg (60 days) dose tothe guinea pig were observed (PATTY (5th, 2001)), it was classified into Category 2 (kidney,liver,adrenal, spleen,hematopoietic systems). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | Insufficient data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |