GHS Classification Result

Chemical Name:disul
CAS:136-78-7

Result:
ID: 777
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible substance
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible
11 Self-heating substances and mixtures Not classified - - - - Not combustible
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Not reacts vigrously with water. The water solubility is obtained.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - Not Classified though containing oxygen bonded to sulfur (not Class: 5.1)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Since there were values of 730 mg/kg and 1500 mg/kg (ACGIH (2001)) as rat LD50 value, it was set as Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - There is no dermal absorptions acute toxicity data, and it cannot be classified.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - There is no data, and it cannot be classified. From oral toxicities data, it is not lethal below the saturated vapor pressure at normal temperature.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Although there is a report that 5% or more of aqueous solutions caused the necrosis on the skin of the rabbit(ACGIH (2001)), irritation is taken in the ICSC card and the EU risk phrase. It is thought that the solution with 5% or less concentration and solid powder causes only irritation on skin contacts. It was classified as Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
There is a report that an irritation is started in the eye of rabbit (ACGIH (2001). Although the original text is unknown, it is indicated that in the rabbit the critical damage was caused by the aqueous solutions 5%. However, it was set as "Category 2A", since R41 was taken in the EU risks assessment phrases.
4 Respiratory sensitization Classification not possible - - - - There is no information on both respiratory sensitization and skin sensitization, and they cannot be classified.
4 Skin sensitization Classification not possible - - - - There is no information on both respiratory sensitization and skin sensitization, and they cannot be classified.
5 Germ cell mutagenicity Classification not possible - - - - There were no in vivo test results, therefore we could not classify it. Likewise, for In vitro tests, there was only a report that the Ames test was carried out (HSDB 82005). The series of Chlorophenoxy herbicides including this substance may contain extremely small quantities of polychlorodibenzo dioxin as the impurities in manufacturing processes, and as a degradation products after production of the products. It is confirmed in the test that these are strong mutagenic substances. It is also suspected as mutagens for human (DHP (13th 2002)).
6 Carcinogenicity Not classified - - - - Since it had classified into A4 according to ACGIH (2001), it carried out "Category Outside." It is suggested that the impurities polychloro dibenzodioxin which described by paragraph of mutagenic, is carcinogenic.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data on toxic to rproduction
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (systemic toxicity)
H335: May cause respiratory irritation (respiratory tract irritation)
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Although the report of the animal experiment was not found out, there are attack, a coma, contracted muscular, relaxation, low blood pressure, nauseousness, vomiting, diarrhea, an abdominal pains, etc. are indicated in human (HSDB (2005), HSFS (2001)). So it is classified into "Category 2 (systemic toxicity)". Moreover, the respiratory irritation was indicated to a ICSC cards (1995) and Sitting (47th. 2002), it was set as "Category 3 (respiratory irritation)."
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
The influences on liver and the kidney were seen within the guidance value of Category 2 in two-year feeding administration to rats. In the given dose within the guidance value of Category 1, effect was not acknowledged with rats and dogs (ACGIH (2001)). There is the statement which is considered to be the human impact, too (HSFS (2001)). It was classified into "Category 2 (liver, kidney)" because of these information.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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