GHS Classification Result

Chemical Name：2-Cyclohexylbiphenyl
CAS：10470-01-6

Result：
ID: 766
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: 157degC (c.c) (ACGIH, 2001)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 374 degC(ICSC (1995); ACGIH (2001)) (>70 degC)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - There are no chemical groups associated with peroxide present in the molecule.
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the lower value LD50=10200 mg/kg (ACGIH (2001)) among two data of rat oral studies, it was classified into outside of Category.
1 Acute toxicity （Dermal） Not classified - - - - Based on the minimal lethal dose (24hr, occluded) of rabbit dermal test being 6800mg/kg (ACGIH (2001)), it was classified as out of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the statement of "moderately irritating" on rabbit test (ACGIH (2001), IUCLID (2000)), it was classified as Category 2.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		There is the statement that "Temporary eye irritation", but in the case that liquid bounds into the eyes in humans, the extent is unknown (ACGIH (2001), and furthermore that there was no irritation in the rabbit test (ACGIH (2001), IUCLID (2000). So it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Based on reports that there is no skin sensitization in the patch tests of 50 [ ACGIH (2001), IUCLID (2000)] and that there is no skin sensitization among 47 laborers according to the epidemiological study(ACGIH (2001)), it was put outside of the Category.
5 Germ cell mutagenicity Not classified - - - - Based on the result (ACGIH (2001)) that it had no mutagenicity in the chromosomal aberration test using the in vivo rat marrow cell, which was an in vivo mutagenicity test using the somatic cells. So we classified it as Out Of Category.
6 Carcinogenicity Classification not possible - - - - Insufficient data available
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into category 2 based on that in teratogenicity studies in rats with the dose causing maternal toxicity (the increase in death, weight reduction), the increase of embryo absortion and rate of post implantational embryo loss, fetal death and teratogenicity (skeletal malformation), etc. are observed(ACGIH (2001), IUCLID (2000)).
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on respiratory irritation being reported by inhalation (ACGIH (2001)), it classified into Category 3 (respiratory irritation) according to rats and humans.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney, brain) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney, brain) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the oral administration examination with a rat and a rabbit, the diffuse degeneration and necrosis of liver, degeneration and a necrosis of a kidney tubular epithelium cell, and cerebral degeneration were observed within the range of exposure 1-10 mg/kg bw (rat) and 4-10 mg/kg bw (rat) (IUCLID (2000)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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