GHS Classification Result

Chemical Name：Cyclohexane
CAS：110-82-7

Result：
ID: 765
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		It was classified as Category 2 (GHS standard: flash point being less than 23 degC, and initial boiling point being more than 35 degC) as its flash point being -20 degC and initial boiling point 80.7 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 245-260degC(ICSC (1994), NFPA (13th, 2002), Chapman (CD-ROM ver. 13.2 2005))
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Not classified because of UNRTDG Class: 3
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on LD50= 7729.9 mg/kg calculated from five data (EU-RAR (2004)) of rats, it was set as the outside of Category.
1 Acute toxicity （Dermal） Not classified - - - - Based on the description that death was not observed at 2000mg/kg of dose in a rabbit (EU-RAR (2004) , it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - The saturated vapor pressure concentration of this product is 125743ppm, and it is thought that all inhalation tests were done with vapor. Based on LC50 of 4-hour exposure on rats >9500ppm (EU-RAR (2004)), it was classified as out of Category.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		There are statements of skin irritation on rabbits and humans (DFGOT vol.13 (1999), EU-RAR (2004), ACGIH (2002), and ICSC (J) (1994)). Although the crack and bleeding was observed on the skin by the repeated administration on rabbits, it recovered in one week after the end of medication (DFGOT vol.13 (1999)). And there is a description that when concentrate solution adhered on humans for 1 hour, it caused redness and wheal (EU-RAR (2004)), but this is also considered to be a disorder of recovery nature. It was classified as Category 2 from what mentioned above.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Since there was a statement that in rabbits corneal cloudings, iritis, conjunctival hyperemias, and chemosis each are seen reversible (EU-RAR (2004), as well as in animals and in humans irritation is in the eye (PATTY (5th, 2001), EU-RAR (2004), ICSC (J), (1994), HSDB (2005)), it was set as Category 2A-2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although a result that did not have skin sensitization in the GLP test is indicated(EU-RAR (2004)), this test is described to have been an inadequate one. On the other hand, it is indicated that there is no example in humans in the reserve column. It was decided that it could not be classified from the above information since data was insufficient.
5 Germ cell mutagenicity Not classified - - - - Based on the fact that there was no result of human over generation epidemiology, over generation mutagenicity test, and the productive cell in vivo mutagenicity test, and based on the negative result in the somatic cell in vivo mutagenicity test (chromosomal aberration test using rat myeloid cells) (DFGOT vol.13 (1999)). So we classified it as Out Of Category according to the technical guideline.
6 Carcinogenicity Not classified - - - - Based on being classified according to EPA with I, it considered as the outside of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into Category 2 based on the statement that in the dosage with parents' weight decrease, or dosage without the statement about general toxicity of parents, the low weight value of the child at the lactation period and an decrease fetal weight are observed, and the influence to the male genitals (atrophia of testis, the spermatic toxicity) was observed (ACGIH (2002), EU-RAR (2004), DFGOT vol.13 (1999)).
8 Specific target organ toxicity - Single exposure Category 2 (cardiovascular system), Category 3 (respiratory tract irritation, narcotic effects) Warning H371: May cause damage to organs (cardiovascular system)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Although there are many statements that central nerve inhibition is reported in many animals tests, and there is many reports about an anesthetic actions, there is no data of the amount of exposure. In oral administration to rabbits, there was a statement that vascular injury was seen by the dosage of guidance value within the Category 2 (ACGIH (2001)), it is classified into Category 2 (vascular systems). A statement that there is respiratory irritation in humans (ACGIH and (2001), ICSC (J) (1994)), central inhibition, such as nausea, unconsciousness, and reflective loss, occurs and it may die (PATTY (5th, 2001)). So it is classified into Category 3 (respiratory irritation, anesthesia action).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - In humans, there is no statement of apparent toxicity development by this substance (ACGIH and (2002),EU-RAR (2004) ) and in animal, development of toxicity is not observed with a given dose higher than the guidance value range of Category 2 (ACGIH and (2002), EU-RAR (2004) and PATTY (5th, 2001)). According to that, it was considered the outside of Category.
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 2 because of "possible to cause chemical pneumonia by misswallowing of the liquid."(ICSC(J), 1999)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour EC50=0.9mg/L of Crustacea (Daphnia magna) (EU-RAR, 2004).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (28-day decomposition rate of the OECD test guideline 301F: 77% (EU-RAR, 2004)), and less bio-accumulative (BCF=129 (Existing Chemicals Safety Check Data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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