GHS Classification Result

Chemical Name:1,3-Dioxolane
CAS:646-06-0

Result:
ID: 762
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Flash point: <23degC, Initial boiling point: >35degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - The ignition points is 274 degC and does not ignite in room temperatures.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not halogen) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. There were two reports of rat LD50. And the lower data of 3000mg/kg (RTECS (2004)) was adopted, it was set as Category 5.
1 Acute toxicity (Dermal) Not classified - - - - Although there are two reports of rabbit LD50, it was 9074mg/kg (RTECS (2004)) when the lower data was adopted. This value became more than 5000mg/kg (dermal LD50 2000mg/kg (Category 4) *2.5), and it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not classified - - - - There are two reports on rat LC50, and the data with lower value is 22574ppm/4h (ACGIH (2002)). The saturated vapor concentration at 20degC is 104000ppm, and it is thought that this test was done with steam. Moreover, since 22574ppm becomes more than 12500ppm: (gas 5000ppm (Category 4) *2.5), it was classified as out of Category.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was classified as Category 3 from the statement of "mild" of the rabbit examination (RTECS (2004)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
It was set as Category 2A from statement of the stimulative (severity rating 8) (ACGIH (2002)) by observation in 72 hours after the examination of the rabbit.
4 Respiratory sensitization Classification not possible - - - - As there is no data, it cannot be classified.
4 Skin sensitization Not classified - - - - Based on a statement that although the skin was exposed repeatedly and irritation was observed, any allergic skin injuries were not observed (ACGIH (2002)), it was put outside of Category.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
There was a negative statement by dominant lethality test of mice (ACGIH (2002)) and positive in micronucleus test in mice with bone marrow cells (ACGIH (2002)), however, there was no report of the productive cell in vivo genotoxicity study. Therefore we classified it as Category 2.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data and reports
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is no report on humans. In an oral administration test to pregnant rats, delayed fetal development and delayed ossification of sternal bones and skuls were observed (ACGIH (2002)). Moreover, although effects on female reproductive ability were not observed but epithelium spotty necrosis of tubulus seminiferus contortus and spermatogenic disorder were observede in microscopy of male testis in the test in which male rats exposed orally or by inhalation were made to mate with non-exposed female rats (ACGIH (2002)). Reduction of coupling and the rate of delivery, increase in the number of stillbirth, and reduction in the number of newborn were observed in mating with male rats administered in drinking water and female rats without treatment(HSDB (2003)). Reduction of the pregnancy rate and the number of delivery of mother animals and decrease of survived offsprings count (F1b) were observed in the test which female rats were copulated with male rats given drinking water administration and were continuously exposed during the pregnancy period and for 10 days after lactation before mating with another male without treatment(HSDB (2003)). In the test which female rats that had mated with male rats administrated in drinking water again mated with new males administrated in drinking water after their delivery, reduction of mating rate, the rate of pregnancy and infant animals' weight of the 21st day(F1b) was observed(HSDB (2003)). It was classified into Category 2 based on the above statement.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Although there is that laboratory animals report of test, since impact is seen only out of the guidance value of category 2, it cannot classify.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although there is report of the laboratory animals test, and effect is seen slightly in all at outside the guidance value of Category 2, since data is insufficient, it cannot be categorized.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 48-hour EC50=6950000microg/L of Crustacea (Daphnia magna) (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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