GHS Classification Result

Chemical Name:Diisobutyl ketone
CAS:108-83-8

Result:
ID: 756
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Category 3 because of its flash point: 49degC(ICSC(J), 1997)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - The ignition points is 345 degC and does not ignite spontaneously in normal temperatures.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Acute oral toxicity is outside of Category. Because rat LD50 value is 5000mg/kg or more, or mortality is not seen in the examination up to 2000mg/kg (SIDS (1998)).
1 Acute toxicity (Dermal) Not classified - - - - Rabbit LD50 value is over 5000mg/kg for females. Although an average is 4579mg/kg in males, it is over 5000mg/kg in re-examination only (SIDS (1998)). Since death was not seen in the rat 2000mg/kg administered test (SIDS (1998)), acute dermal toxicity is outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - There is a report that even if rats are exposed to 5mg/L or saturated vapor pressure (about 13mg/L) for 4 hours, there was no mortality (SIDS (1998)). But this data is not sufficient for the classification. Since death was not observed with 13mg/L, it is presumed to be Category 4, Category 5 or outside of Category.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - The mean score value of 24 - 72 hours acquired in the test of SHELL according to OECD Guideline was 0.3-0.6, which is below the judging standard of Category 3. (SIDS (1998)). Moreover, the result of having evaluated the test results of Potokar according to OECD Guideline by the standard of EEC was non-irritannt (SIDS (1998)). Therefore, it was classified as out of Category.
3 Serious eye damage/eye irritation Not classified - - - - Each of three test results reported is slight stimuli, and is not classified into eye irritation (SIDS (1998), DFGOT vol.18 (2002)).
4 Respiratory sensitization Classification not possible - - - - As there is no data, it cannot be classified.
4 Skin sensitization Not classified - - - - Results of the maximization test with guinea pigs and the Magunusson & Kligman test that it is not sensitizing has been obtained. (SIDS(1998))
5 Germ cell mutagenicity Classification not possible - - - - Although many negative results were obtained for the in vitro tests, the information on in vivo tests is inadequate. (SIDS(1998))
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Not classified - - - - Since it is reported no effects on reproductive function and implantation count of parents, and neonatal live birth count in administration test for 2weeks before mating to lactational period (SIDS (1998)), it was considered as the outside of category according to .
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is the data that upper respiratory mucous was stimulated in mouse (DFGOT vol.18 (2002)), there is a report of respiratory irritation in humans (DFGOT vol.18 (2002), PATTY (2001)). And it has classified into respiratory irritation (Xi: R37 Iriitating to respiratory system) according to EC-AnnexI, it is classified into category 3 (respiratory irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although there is a report that effect is observed by internal organs, such as the adrenal gland, liver, and the kidney, in the test with rats in inhalation administration at 925 ppm or more for six weeks by Carpenter (1951, 1953) etc., this occured with the concentration quite higher than the maximums of the guidance value of Category 2 converted into six weeks, which is 500 ppm (SIDS (1998)). Although slight affect is seen to liver at 250 ppm which is lower than 500 ppm of maximums of the guidance value of Category 2 converted into six weeks, in the inhalation test for six weeks with gunea pig by Carpenter (1951, 1953) etc., there is a reportthat it is not regarded as significant affect to organ (SIDS (1998)) . However, it was considerd that it cannot be classified due to not performing all the evaluations, that impact is seen slightly in the place near a guidance value, and there is no humans report.
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ...
The dynamic viscosity at 21 degree C is 1.1mm2/s (calculated from The Solvent Pocket Book data), and diisobutyl ketone is a ketone with a carbon number of 13 or less, therefore we classified it as Category 2.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 96-hour LC50=140mg/L of fishes (Rainbow trout) (SIDS, 2004).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (aqueous solubility ==2640 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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