GHS Classification Result

Chemical Name:diazomethane
CAS:334-88-3

Result:
ID: 748
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases (including chemically unstable gases) Category 1 Danger H220: Extremely flammable gas P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P381: Eliminate all ignition sources if safe to do so.
P403: Store in a well-ventilated place.
Ignitable if there is an ignition source, because of "its auto-ignition temperature: 100degC" (ICSC(J), 1995)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not classified - - - - Not oxidizing gas because of flammable gas
5 Gases under pressure Not applicable - - - - Impossible to store or transport as pure articles
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solids Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Test methods are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - No data available
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Classification not possible - - - - It cannot be classified. Since concentration is unknown in rat inhalation exposure, test time of others is slight, and there is no valid data used for classification. (In these exposure examinations, having died for a short times, and death in 10 minutes in cat inhalation study at 175ppm (4 hour equivalent: 35ppm). It seems that treating as Category 1 is desirable since this is less than 100ppm of Category 1.)
1 Acute toxicity (Inhalation: Vapours) Not applicable - - - - Gas (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
It was classified as Category 2 as it was reported that there is stimulativeness and denudation on human skin (ACGIH (2001)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Since there was a case of severe inflammation (critical inflammation) to humans, it was set as Category 1. (DFGOT vol.13(1999)
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
Based on the case which caused the attack of asthma in humans(ACGIH (2001)) respiratory sensitization was referred to as Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Skin sensitization was set to Category 1 since sensitization was identified in guinea pigs (PATTY (5th, 2001)). Diazomethane is defined as a sensitizing chemical substance in the interim report of the Japanese occupationl and environmental allergology meeting's specially committee .
5 Germ cell mutagenicity Classification not possible - - - - Although it showed mutagenicity for the in vitro information (DFGOT vol.13 (1999)), there was no in vivo data. Therefore we could not classify it.
6 Carcinogenicity Not classified - - - - It carried out the outside of Category by classification called three of IARC.
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system), Category 2 (spleen, liver) Danger
Warning
H370: Causes damage to organs (respiratory system)
H371: May cause damage to organs (spleen, liver)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
There is cases, such as pneumonia, pulmonary oedema, difficulty breathings, cyanosis, chest pain, asthma, and generation of heat, are regarded in humans (ACGIH (2001), PATTY (5th, 2001), IARC 7 (1974)), so it is classified into Category 1. Moreover, in the examination of a rat, atelectasis, purulence and hyperemia of bronchus, emphysema, dysplasia of bronchus mucosa, etc., moreover, congestion and expansion of spleens, nephrotic changes in half of liver cortex inner side, and ongestion of glomerulus (IARC 7 (1974), DFGOT vol.13 (1999)). Thereby, it is classified into Category 2 (a spleen, liver).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - It cannot be classified, accoding to that in the human case, there are the examples that pulmonaru edema, asthma, respiratory distress, cyanosis, and a tremor has come out and, died and the other hand recover ten days afterward (DFGOT vol.13 (1999)). These occupational exposure is considered to be the results out of which the symptom of acute toxicity (single exposure) came.
10 Aspiration hazard Not applicable - - - - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

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