GHS Classification Result

Chemical Name：Diacetone alcohol
CAS：123-42-2

Result：
ID: 747
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since flash point of reagent grades was 66 degC, it was classified as Category 4. (Since industrial pure product diacetone alcohol includes acetone, there is also data that indicates 8 degC of flash point. Therefore, it is class 3 Division II and III in the UN Recommendations. Such commercial items with low flash point are classified as Category 2).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - The ignition points is 603 degC and there is no spontaneous combustibility in normal temperatures.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available on corrosion to metals

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. SPECIES: Rat ENDPOINT: LD50 VALUE: 4000 mg/kg REFERENCE SOURCE: SIDS (2000)
1 Acute toxicity （Dermal） Not classified - - - - Since the value (SIDS (2000)) of rabbit LD50= 13630mg/kg had exceeded 5000mg/kg (Category 5), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Since there is no LC50 value, it cannot be classified. (It is assumed to be Category 3 to out of Category, since no death was observed on rats with 7.23g/m3 (1520ppm) (SIDS (2000)))
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was classified as Category 2 based on the information of moderate irritation in irritation test on rabbits (SIDS (2000)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		It was set as Category 2A using information of moderate or highly irritating with a rabbit (SIDS (2000), PATTY (5th, 2001)), and that there is irritation with humans (SIDS (2000), ACGIH (2001)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - There were reports that it gave negative in vitro (SIDS (2000), PATTY (5th, 2001)), however, there was no in vivo information. Therefore we could not classify it.
6 Carcinogenicity Classification not possible - - - - Since there is no information and other test data by evaluation organizations, it cannot be classified.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it is observed of declines conception rate, implantation count and implantation rate of reproductive potential and declines of total newborn count, delivery rate, neonatal count, live birth index, 4-days neonatal survival count and viability index on day 4 of offspring developmen (SIDS 2000)), it is classified into category 2.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system), Category 2 (liver), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (respiratory system)
H371: May cause damage to organs (liver)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Since respiratory irritations and pulmonary diseases (SIDS (2000), ACGIH (2001)) are seen in human cases, it was set as Category 1 (respiratory system), and by the data that cases of liver is seen by 2ml/kg (equivalent : 1860mg/kg) rat oral taking (ACGIH (2001), PATTY (5th, 2001)), so it was set as category 2 (liver) from a guidance value. Since the anesthetic actions was seen in the animal (ACGIH (2001), PATTY (5th, 2001)), it is classified into Category 3.
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney) Danger H372: Cause damage to organs through prolonged or repeated exposure (kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classfied into Category 1 (kidney) accoding to the description that "onset of nephrotic syndrome is used as the evidence of proliferative glomerulonephritis." in example of accident of humans at diacetone alcohol and ethanol exposure (PATTY (5th, 2001)).
10 Aspiration hazard Classification not possible - - - - No data available on chemical pneumonia

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - it carried out the outside of Category from 96-hour LC50>100mg/L of fishes (Oryzias latipes), and others (MOE eco-toxicity tests of chemicals, 1996).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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