GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Methyl acetate
CAS：79-20-9
Result：
| ID: | 735 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 2 |
|
Danger | H225: Highly flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Flash point: -10degC(<23degC), Boiling point: 56.9degC(>35degC) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Flash point: 455degC (ICSC, 1997) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements). |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | SPECIES: Rat ENDPOINT: LD50 VALUE: > 5000 mg/kg REFERENCE SOURCE: DFGOT vol.18 (2002) SPECIES: Rat ENDPOINT: LD50 VALUE: 6482 mg/kg REFERENCE SOURCE: EU-RAR (2003) |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on rat LD50 >5000mg/kg (DFGOTvol.18 (2002)), it was set as the outside of Category. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Not classified | - | - | - | - | Based on the descriptions that 6/6 survival with 16000ppm/4h, 6/6 death with 32000ppm (DFGOTvol.18 (2002)) and rat LC50 >16170ppm/4h (EU-RAR (2003)), it was classified as out of Category |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | Based on the descriptions that it has no stimulation with application on humans (EU-RAR (2003),(DFGOTvol.18 (2002)) and that it has no stimulation on rabbits (EU-RAR (2003)), it was classified as out of Category. |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
According to statements that there was eye irritation by exposure to vapors to humans (EU-RAR (2003)), severe irritation (a stimulus of a cornea and the iris, redness of a conjunctiva, dropsy, bleeding) was accepted by the test of the rabbit, and the recovery on less than the 7th was also observed (EU-RAR (2003)). And it was segmented into Category 2B. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Since there is no data, it cannot be classified. |
| 4 | Skin sensitization | Not classified | - | - | - | - | It was put outside of the Category because a statement says that sensitization was not identified in a maximization test conducted by volunteers(EU-RAR (DFGOTvol.18 (2002)) (2003)). |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | There was a statement that it gave negative result in the rat micronucleus test (erythrocyte) (EU-RAR (2003)), and we classified it as Out Of Category according to the technical guideline. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data and reports |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system), Category 3 (respiratory tract irritation) |
|
Danger Warning |
H370: Causes damage to organs (nervous system) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
It is classified into Category 3 (respiratory irritation) by the statement of the stimulativeness of a respiratory tract and the pharynx in humans (PATTY (5th, 2002), DFGOTvol.18 (2002), ACGIH (2001), EU-RAR(2003)). There are dizziness, vertigo, headache, an unstable walk, vision disappearance of both eyes, withering of an optic nerve, scotoma expansion of a left eye, the tunnel vision of a right eye, and the anesthesia action (EU-RAR (2003)) to occupational exposure in humans , it is classified into Category 1 (nervous systems). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Since data is insufficient, it cannot be classified. (The adverse effects in the animal studies was seen by exposure concentration higher than a guidance value.) |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | It carried out the outside of Category from 72-hour EC50>120mg/L of algae (Green algae) (EU-RAR, 2003). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since not water-insoluble (aqueous solubility =2.43*105mg/L (PHYSPROP Database, 2005)) and acute toxicity is low. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |