GHS Classification Result

Chemical Name：1-methylbutyl acetate
CAS：626-38-0

Result：
ID: 733
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: <32degC, Boiling point: 121degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Not ignite spontaneously on coming into contact with air at normal temperatures
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - It is a value in an isomer mixture. But there is the report (DFGOT vol.11 (1998)) that rat LD50 is 6500mg/kg, it was set as the outside of Category.
1 Acute toxicity （Dermal） Not classified - - - - It is a value of isomer mixture. But there is a report (ACGIH (2001), DFGOT vol.11 (1998)) that rabbit LD50 : 17400mg/kg or more, it is considered as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - There is a report that even if rats are exposed to the saturated vapor (about 5200ppm) of the pentyl acetic acid isomer mixture (most is 1-pentyl acetate) for 4 hours, there is no mortality (ACGIH (2001), DFGOT vol.11 (1998)). But this data is not sufficient for the classification. Category 5 or out of Category is presumed from this data.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - There is a report on isomer mixture that skin irritations in short-term exposure is thought to be weak or none (ACGIH (2001), DFGOT vol.11 (1998)). Therefore, it was classified as out of Category. Skin irritation and defatting of the skin were observed in repeated exposure.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		There is eye irritation in the human vapor exposure (ACGIH (2001), PATTY (2001)). And weak eye irritations is admitted in the test dropped at the eye of the rabbit (ACGIH (2001)). So it is set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Although sensitization is not identified in humans [ ACGIH and (2001) ] DFGOT vol.11 (1998), weak sensitization has been identified in animal tests(ACGIH (2001), PATTY (2001)). Therefore it is referred to as Category 1.
5 Germ cell mutagenicity Classification not possible - - - - In the in vitro examination of pentyl acetates, we found the reports that it had no mutagenicity or weak if any (ACGIH (2001), PATTY (2001), DFGOT vol.11 (1988)), however, there was no report of the in vivo examination. Therefore we could not classify it.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Classification not possible - - - - Although there is data which has"no effects" on pregnant females of rats and of rabbits, since there is no impact data on genitalia of male, it cannot be classified.
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system), Category 3 (narcotic effects) Warning H371: May cause damage to organs (respiratory system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		In humans, it has the effect on lungs (RTECS (2001)). In guinea pig inhalation study, effects on the lungs is seen within the guidance value of category 2 (ACGIH (2001)). Moreover, since respiratory irritation is seen in humans (DFGOT vol.11 (1998)) also in an animal studies (ACGIH (2001)), it is set as Category 2 (respiratory systems). Since having an effect of anesthetic actions (ACGIH (2001)) and lethargica (RTECS (2004)) in inhalation tests in animals is reported, it classifies into Category 3 (anesthetic actions).
9 Specific target organ toxicity - Repeated exposure Category 1 (optic nerve), Category 2 (spleen, kidney, liver) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (optic nerve)
H373: May cause damage to organs through prolonged or repeated exposure (spleen, kidney, liver) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Acting on the human optic nerve is reported. Moreover, it was classified into Category 1 (optic nerve) according to that the optics nerve effects is observed also in the test using a rabbit (DFGOT vol.11 (1998)). In the study using a rabbit in the range of guidance values of Category 2, affecting the organization and function of these internal organs such as hypertrophy of a spleen follicle, trabecura of spleen sclerosis,and the congestion of renal glomerulus and kidney tubules, and fatty degeneration of liver are reported (DFGOT vol.11 (1998)). According to that, it was classified into Category 2 (a spleen, kidney, liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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