GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Benxyl acetate
CAS：140-11-4
Result：
| ID: | 731 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 4 | - | Warning | H227: Combustible liquid |
P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Flash point: >60degC and <=93degC |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | It is the liquid with ignition points of 460 degC (ICSC (1999)) and it does not ignite in room temperatures. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements). |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 5 | - | Warning | H303: May be harmful if swallowed | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | SPECIES: Rat ENDPOINT: LD50 VALUE: 2490 mg/kg REFERENCE SOURCE: ACGIH (2001) |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | It was set as the outside of Category from rabbit LD50: >5000mg/kg (IUCLID (2000)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
It was classified as Category 2 because of the statement of moderate on rabbits (RTECS (2005)). |
| 3 | Serious eye damage/eye irritation | Category 2A-2B |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
It was segmented into Category 2 from the statement of eye irritation (IARC 40 (1986)). Since there is no descriptions of reparable, subdivide Category of 2A and 2B is not made. It is more desirable to be set as 2A from a viewpoint of safety, when subdivision needs to be performed by display etc. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Since there is no data, it cannot be classified. |
| 4 | Skin sensitization | Not classified | - | - | - | - | It was put outside of the Category according to the negative statement(IUCLID (2000)) of the test which was made by volunteers and that of the test using guinea pigs(ACGIH (2001)) . |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on the descriptions (IARC 71 (1999)) that it gave negative result for the sister chromatid exchange test in mouse, negative for the micronucleus test which used the mouse marrow erythrocyte, negative for the micronucleus test which used the mouse peripheral blood, negative for the chromosomal aberration test which used the mouse marrow cells (all were in vivo). So we classified it as Out Of Category. |
| 6 | Carcinogenicity | Not classified | - | - | - | - | It carried out the outside of Category from it being classified into A4 according to ACGIH, and being classified into the group 3 according to IARC. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system, central nervous system), Category 3 (narcotic effects) |
|
Danger Warning |
H370: Causes damage to organs (respiratory system, central nervous system) H336: May cause drowsiness or dizziness (narcotic effects) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
There is the statement that respiratory irritation and anesthetic actions in humans (NTP TR250 (1986)), and pulmonary congestion, and pulmonary edemas in mouse by steam exposure in the guidance value of category 1 (ACGIH (2001)), and inhibitation of central nerve (NTP TR431 (1993)). So it segmented into 1 (respiratory system, central nerves) and Category 3 (anesthetic actions). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (kidney), Category 2 (nasal mucosa) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (kidney) H373: May cause damage to organs through prolonged or repeated exposure (nasal mucosa) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
It was classified into Category 1 (kidney) because of the statement that it occures disorders in the kidney of the humans by continuous inhalation exposure (NTP TR250 (1986)) . It was classified into Category 2 (nasal mucosas) because of the statement that atrophy and degeneration of nasal mucosas, hyperplasia of nasal submucosal, and the pigmentation of the nasal-mucosa epithelium were observed in feed administration to mice, within the guidance value of Category 2 (NTP TR431 (1993)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 96-hour LC50=4mg/L of fishes (Oryzias latipes) (ECETOC TR91, 2003). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since rapidly degrading (BOD: 95% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=1.96 (PHYSPROP Database, 2005)). |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |