GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Propyl acetate
CAS：109-60-4
Result：
| ID: | 729 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 2 |
|
Danger | H225: Highly flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Category 2 because of its flash point: 13degC, initial boiling point: 101.6degC, and UNRTDG Class: 3, PGII |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Flash point: 430-450degC (Chapman , 2005; ICSC, 1996) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Not classified because of UNRTDG Class: 3 |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements). |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Based on LD50 value = 9.8 ml/kg (8700 mg/kg) in oral administration in rats (ACGIH (7th, 2001)), it was set as the outside of Category. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on LD50 >20ml/kg (reduced value: >17720mg/kg) (ACGIH (7th, 2001)) in rabbit dermal administration, it was set as the outside of Category. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 5 | - | Warning | H333: May be harmful if inhaled | P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. | Based on the statements that 4 among 6 rats died with 8000ppm (ACGIH (7th, 2001)) and that LCLo = 8000ppm (IUCLID (2000)), LC50 value was considered to be close to 8000 ppm. And it was classified as Category 5. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | As the result of open irritation test on rabbit was reported to be "mild" (RTECS (2005)), it was classified as Category 3. |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
It was set as Category 2B based on the statement (RTECS (2005)) that the result of Draize tests by rabbits was "mild." (RTECS (2005)) In addition, the irritant against eyes is reported in the exposure tests using a cat (ACGIH (7th, 2001)) and also humans (HSDB (2005)). Moreover, the this product is classified into R 36 by EU. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system), Category 2 (liver), Category 3 (respiratory tract irritation, narcotic effects) |
|
Danger Warning |
H370: Causes damage to organs (central nervous system) H371: May cause damage to organs (liver) H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
There is a statement that respiratory irritation and central nerve inhibition occur to humans (PATTY (5th, 2001)), and there is a effect possibility to central nervous systems and liver (HSFS (2001)). And there is a publication of salivation (10.9 mg/L, ACGIH (7th, 2001)) and a staggering gaits (30.9 mg/L, PATTY (5th, 2001)) in a cat, and stillness (exposure dosage ignorance, RTECS (2005)) in a rat, and the central action is suggested. There is a publication of an anesthesia action in cat and mice (ACGIH (7th, 2001), PATTY (5th, 2001), RTECS (2005)). On the other hand, there is a statement that the animal which assumed the deep anesthesia state was recovered quickly (GESTIS (2005)). It is classified into Category 1 (central nervous system), 2 (hepatic), and 3 (respiratory irritation, anesthesia action) based on these information. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data available |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 96-hour LC50=60mg/L of fishes (Fathead minnows) (HSDB, 2004). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since rapidly degrading (BOD: 81% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=1.24 (PHYSPROP Database, 2005)). |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |