GHS Classification Result

Chemical Name:enflurane
CAS:13838-16-9

Result:
ID: 710
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Non-combustible (ICSC(J), 2002).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Not combustible (ICSC (J), 2002)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(J) (2000))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen, fluorine and chlorine and these elements are chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Not classified because of SPECIES: Rat; ENDPOINT: LD50;VALUE:5450 mg/kg; REFERENCE SOURCE: DFGOT vol. 9 (1998)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not classified - - - - Since the saturated vapor pressure concentration of this product is 780000ppm, it is thought that the test was performed with steam. Based on LC50 of 3-hour exposure on rat = 14000ppm (4 hour exposure equivalent: 12100ppm) (DFGOT vol.9 (1998)), it was classified as out of Category.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was classified as Category 3 based on the statement that the skin may be stimulated and redness and dryness may be caused (ICSC (J) (2002)) .
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
It was set as Category 2A-2B based on the statement that an eye was stimulated and redness and pain are produced (ICSC (J), (2002)).
4 Respiratory sensitization Classification not possible - - - - Although there is a publication that allergic asthma was caused(DFGOT vol.9 (1998)) , it is not known whether the symptom was induced only by those who have bronchia hypersensitivity, and besides that there is another publication too that it may serve as a trigger of bronchospasm in an asthmatic patient(DFGOT vol.9 (1998)). This substance is not listed in MAK/BAT (2004) as a sensitization. It was decided, based on the above mentioned, that it could not be classified due to the insufficiency of data.
4 Skin sensitization Classification not possible - - - - No data
5 Germ cell mutagenicity Not classified - - - - Based on the statement that neither the malformation of a sperm nor the chromosome aberration of the spermatogenous cells was acknowledged in the 78-week inhalation study in the mouse (DFGOT vol.9 (1998)), and based on the statement (DFGOT vol.9 (1998)) that neither the sister chromatid exchanges nor the increase in the chromosomal aberrations was acknowledged in the human who received occupational exposures or anesthesia. So we classified it as Out Of Category according to the technical guideline.
6 Carcinogenicity Not classified - - - - Based on being classified into group 3 (Gangolli (2nd, 1999)) according to IARC, and being classified into A4 (ACGIH (2001)) according to ACGIH, it carried out the outside of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since although there is no statement on parents' toxicity in mice, there is a statement that cleft palates and a few abnormalities of internal organs and scaffold on offsprings were observed (DFGOT vol.9 (1998)), there is a statement of a relationship between exposure to this substance and the increase in miscarriages and congenital anormaly in humans (SITTIG (4th, 2002)), it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (cardiovascular system), Category 3 (narcotic effects, respiratory tract irritation) Warning H371: May cause damage to organs (cardiovascular system)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
There are the description that there is an anesthetic actions in humans, and a description that the fall of judgment and learning ability, the influence of amnesia and on the other center nerve were seen after exposure (DFGOT vol.9 (1998), ICSC (J) (2002), SITTIG (4th, 2002)). Moreover, there is the description (ICSC (J) (2002)) that an respiratory tract may be irritated and a cardiovascular systems may be affected. It is classified into Category 2 (cardiovascular system) and Category 3 (anesthetic actions, respiratory irritation) based on the above information.
9 Specific target organ toxicity - Repeated exposure Category 2 (central nervous system, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (central nervous system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It was classified to as Category 2 (central nervous systems,liver) based on the statementthat the bad influence to an epilepsy seizure and liver is seen in the human high exposure levels (SITTIG (4th, 2002)) .
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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