GHS Classification Result

Chemical Name:Cumene
CAS:98-82-8

Result:
ID: 705
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
It was classified as Category 3 based on flash point: 31 degC and UN No.1918 Class: 3 Packing group III.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 420degC (ICSC, 2000)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - There are no chemical groups associated with peroxide present in the molecule.
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3, PG III

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was classified into Category 5 based on 2210 mg/kg which was done the statistical culculation of rat LD50 (1400, 4000, 1400, 2910, 2700, 3980, and 4750 mg/kg ((CERI Hazard Data ((1999)), ACGIH ((2001)), EU-RAR ((2001)), and PATTY ((5th, 2001))).
1 Acute toxicity (Dermal) Not classified - - - - It was classified as outside of Category since rabbit LD50s were >10 and 10.6g/kg (CICAD 18 (1999), EU-RAR (2001)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Examination concentration of 3577ppm for 6hr on rat (4hr equivalent: 4381ppm) (ACGIH (2001)) corresponds to Category 4. But it presupposed that it cannot be classified since death is not observed. Moreover, examination concentration of 20mg/L for 4hr on rats (EU-RAR (2001)) corresponds to Category 4. But it presupposed that it cannot be classified since death is not observed.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Rat LC50 = 8000ppm (39.3mg/L) (ACGIH (2001)) is more than saturated vapor pressure pressures concentrations (4215ppm), and it was judged to be an examination in mist. It was set as the outside of Category based on the guidance value of mist.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. As for rabbits, some show moderate stimulativeness (DFGOT vol.13 (1999)). But most show mild irritation (ACGIH (2001), EU-RAR (2001), and CICAD 18 (1999)), and it was not classified as "skin irritative" in EU. So it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
By two Draize examinations, mild irritation (ACGIH (2001), EU-RAR (2001)), and others, from middle to severe edemas and erythema of the conjunctiva are reported by individual reports (DFGOT vol.13 (1999)). Except these one, slight irritation or stimulativeness altogether (ACGIH (2001), CICAD 18 (1999), DFGOT vol.13 (1999), EU-RAR (2001)). Moreover, there is a report that it recovers within five days (ACGIH (2001), CICAD 18 (1999)). Furthermore, it is not classified into "eye irritation" according to the EU classification. It classified into Category 2B from these things.
4 Respiratory sensitization Classification not possible - - - - Since there was no data, it was decided that It could not be classified.
4 Skin sensitization Not classified - - - - Based on the two reports (ACGIH (2001) and CICAD 18 (1999)) that no skin sensitization was identified in the maximization test, it .was put outside of the Category.
5 Germ cell mutagenicity Not classified - - - - Based on the two negative results (ACGIH (2001), CICAD 18 (1999), DFGOT vol.13 (1999), EU-RAR (2001)) of the in vivo mouse micronucleus examination, we classified it as Out Of Category. In addition, all in vitro examinations were also negative and the results support the classification as "Out Of Category."
6 Carcinogenicity Not classified - - - - Since the classifications of EPA were "D and CBD", they classified out of Category.
7 Reproductive toxicity Classification not possible - - - - No developmental toxicity to a neonatal in rat and rabbit examinations is obvious (ACGIH (2001), CICAD 18 (1999), DFGOT vol.13 (1999), EU-RAR (2001), IRIS (2005)). However, since there is no data about the reproductive function and reproductive potential by the exposure in premating, it is considered as it cannot be classified.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 2 (liver, kidney, blood), Category 3 (narcotic effects, respiratory tract irritation) Danger
Warning
H370: Causes damage to organs (central nervous system)
H371: May cause damage to organs (liver, kidney, blood)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Many influences of a central nervous systems are reported (ACGIH (2001), CICAD (J)18 (1999), EU-RAR (2001), DFGOT vol.13 (1999)), and it was set as Category 1 (central nervous system) from dosage and a guidance value. Moreover, the affect on liver and the kidney (EU-RAR (2001)) and the affect on leukocyte (DFGO vol.13 (1999)) are reported. It was set as category 2 (liver, kidney, blood) from dosage and a guidance value. Furthermore, an anesthetic action (ACGIH (2001), DFGOT vol.13 (1999), EU-RAR (2001)) and respiratory irritation (ACGIH (2001), DFGOT vol.13 (1999)) are reported. It was set as Category 3 (anesthetic action, respiratory irritation).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since the effect to central nervous systems in humans was reported (PATTY (5th, 2001)), it was classified to Category 1 (central nervous systems).
10 Aspiration hazard Category 1 Danger H304: May be fatal if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ...
It is a hydrocarbon and dynamic viscosity is not over 20.5mm [2/s ]. And, there was a description "when the fluid is swallowed, there is a risk of chemical pneumonia by aspiration" (ICSC(ICSC(J), (2000))). Moreover, it is classified as R65 in EU. Therefore, we classified it into Category 1.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 96-hour LC50=1.2mg/L of Crustacea (Mysid shrimp), and others (CICAD18, 1999).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 2, since acute toxicity was Category 2 and not rapidly degrading (BOD: 33% (existing chemical safety inspections data)), though supposed less bio-accumulative (log Kow=3.66(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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