GHS Classification Result

Chemical Name:Ethyl formate
CAS:109-94-4

Result:
ID: 702
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Flash point: -20degC, Boiling point: 53 to 54degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - It is the liquid with ignition points of 440 degC (ICSC (1998)), and it does not ignite in room temperatures.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
SPECIES: Rat ENDPOINT: LD50 VALUE: 1850 mg/kg REFERENCE SOURCE: DFGOTvol.19 (2003)
1 Acute toxicity (Dermal) Not classified - - - - Based on rabbit LD50: >5000mg/kg (IUCLID (2000)), it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. Based on rat LC50 value: 4000 - 8000ppm (ACGIH (2001)), it was classified as Category 5. (The saturated vapor concentration at 20degC is 3.2*10^(5) ppm)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - Based on descriptions that it has no stimulativeness on rabbits (DFGOTvol.19 (2003)) or on humans (DFGOTvol.19 (2003) and IUCLID (2000)), it was classified as out of Category.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
There are statements of the moderate stimulativeness in the human exposure to vapor (HSDB (2005)), inflammation of a cornea by rabbit test (DFGOTvol.19 (2003)) and moderate stimulativeness (IUCLID (2000)). But there is no resilience data, and Category of 2A and 2B is not made. When a display is required, it is recommended to be set as 2A from a viewpoint of safety.
4 Respiratory sensitization Classification not possible - - - - There is no data.
4 Skin sensitization Not classified - - - - It was put outside of the Category based on a statement of volunteering test indicating non-exsistence of the sensitization (IUCLID (2000)).
5 Germ cell mutagenicity Classification not possible - - - - We found the negative result for the in vitro test (the Ames test, negative), however, we found no in vivo report. Therefore we presupposed that we could not classify it according to the technical guideline.
6 Carcinogenicity Classification not possible - - - - There was a statement of negative in percutaneous tests (PATTY (2001)), (DFGOTvol.19 (2003)). But there is no data of taking orally of of inhalation and there is also no information of evaluation organizations, such as IARC. So it was presupposed that it cannot be classified.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects, Respiratory tract irritation) Warning H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
There are the description that there is anesthetic action, irritation to nose in human exposure (ACGIH (2001)), it is classified into Category 3 (anesthetic action, respiratory irritation). The symptoms which is reported in the animal test was seen out of the amount of the administration of the guidance value of the Category 2.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data on chemical pneumonia, though Dynamic viscosity: 0.434mm2/s.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 96-hour LC50=230mg/L of fishes (Rainbow trout). (IUCLID, 2000)
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (aqueous solubility = 88200 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information