GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Gasoline, natural
CAS：8006-61-9
Result：
| ID: | 699 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not classified | - | - | - | - | UNRTDG No. 1203, Class: 3 |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (room temperature) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (room temperature) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (room temperature) |
| 6 | Flammable liquids | Category 2 |
|
Danger | H225: Highly flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Category 2 because of its flash point: -45degC, initial boiling point: 39degC, and UNRTDG Class: 3, PGIII |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (room temperature) |
| 8 | Self-reactive substances and mixtures | Not classified | - | - | - | - | Classified in UNRTDG No. 1203, Class: 3 |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Flash point: about 300degC (>70degC) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (room temperature) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | UNRTDG Class: 3 No.1203 |
| 13 | Oxidizing liquids | Not classified | - | - | - | - | UNRTDG No. 1203 Class: 3 |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (room temperature) |
| 15 | Organic peroxides | Not classified | - | - | - | - | UNRTDG No. 1203 Class: 3 |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to liquid substances with boiling point of >55degC are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | It was set as the outside of Category based on that rat oral LD50 value (14063mg/kg (ATSDR (1995))) was 5000mg/kg or more. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | It became the Category 4 to outside of Category from rabbit percutaneous LD50 values (> 2000mg/kg, > 3750mg/kg (IUCLID (2000)). but it cannot be classified since it cannot be decided. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (room temperature) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | It is Category 3 - out of Category based on rat inhalation LC50 value (>5.2 mg/L (IUCLID (2000))), it was cannot be decided and so cannot be classified. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
The result obtained in 4 hour contact test of the agents on rabbit skin irritation with Draize's method (Draize score 4.8 (IUCLID (200)), it was classified as Category 2. |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
By a statement that an eye is stimulated by gasoline vapor exposures in humans(ACGIH (2001)) and based on not irritating in rabbit eye irritation test (ATSDR (1995)), it was set as Category 2B. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data |
| 4 | Skin sensitization | Not classified | - | - | - | - | Since a result that the guinea pig test proved no sensitization has been obtained[ ATSDR (1995) ].)., it was put ouyside of the Category. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | It gave negative in dominant lethality test using the mouse (IUCLID (2000)), and it also gave negative in the rat marrow cell in vivo chromosomal aberration test (IARC 45 (1989)). Therefore we classified it as Out Of Category based on the technical guideline. |
| 6 | Carcinogenicity | Category 2 |
|
Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
It was set as 2 based on the carcinogenic segment A3 by ACGIH (1996). |
| 7 | Reproductive toxicity | Not classified | - | - | - | - | Any significant reproductive toxicity has not been observed in the two generation reproduction studies with exposing for two weeks before mating to male/female rat and during pregnancy (IUCLID (2000)). Moreover, teratogenicity has not been observed in the teratogenicity test that followed OECD TG414 (IUCLID (2000)). Therefore, it was placed out of classification. [Special notes] In addition, increase in cleft palates and the number of survived litters has been observed in reproductive toxicity studies of mice, but this was the result at the highest dose with mother animals lethality reached 44%, while no statement of reproductive toxicity at any lower rate is found. Therefore, since the increase in cleft palates and fetal mortality is considered to have been caused of the toxicity against maternal animals, it is not used as referrence for this classification. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (lung, kidney), Category 3 (narcotic effects) |
|
Danger Warning |
H370: Causes damage to organs (lung, kidney) H336: May cause drowsiness or dizziness (narcotic effects) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
There is the description that the amount of the oral ingestion and the inhalation exposure in the high concentration in human causes pneumonitis (PATTY (5th, 2001)), disorders of kidney (ATSDR (1995)), and it is classified into Category 1 (respiratory tract, kidney). Moreover, it is classified into Category 3 (anaesthetic) by the description that there are a coma and anaesthetic by inhalation exposure to humans (PATTY (5th, 2001), ATSDR (1995)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system), Category 2 (blood vessels) |
|
Danger Warning |
H372: Cause damage to organs through prolonged or repeated exposure (nervous system) H373: May cause damage to organs through prolonged or repeated exposure (blood vessels) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
It was classified to as Category 1 (nerve) based on the statement that C4-C7 hydrocarbon in gasoline may cause the sensitization of a cardiac muscle, acute central inhibition, and a respiratory insufficientry in humans (PATTY (5th, 2001)). It was classified to as Category 2 (vascular) because that vascular atrophy and a necrosis are observed in the rat long-term inhalation study (PATTY (5h, 2001)). In addition, the nephrotoxicity to the male rat observed in the repetitive atmospheric exposure test of the gasoline using a rat is a symptoms peculiar to a male rat, and it is not applied to humans. (IUCLID(2000)) |
| 10 | Aspiration hazard | Category 1 |
|
Danger | H304: May be fatal if swallowed and enters airways |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P331: Do NOT induce vomiting. P405: Store locked up. P501: Dispose of contents/container to ... |
Category 1 because of "human beings cause aspiration pneumonia by an oral ingestion of gasoline." (HSDB, 2004) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 96-hour LC50=82mg/L of fishes (Sheepshead minnow) (IUCLID, 2000). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 3 | - | - | H412: Harmful to aquatic life with long lasting effects |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 3, since acute toxicity was Category 3 and rapid degradability and bioaccumulation potential are unknown. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |