GHS Classification Result

Chemical Name:Morpholine, 4-ethyl-
CAS:100-74-3

Result:
ID: 671
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Category 3 because of its flash point: 32 to 38degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 185-240degC (ACGIH, 2001; ICSC, 2002; GESTIS, 2005)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Diluent type A >=48%, Available oxygen >10% and <=10.7%, UNRTDG No.3101, Class:5.2, GHS Classification, Organic peroxides type B
16 Corrosive to metals Classification not possible - - - - Although considered as the class 8 (caustic substances) in subsidiary risks in UN No.2924 FLAMMABLE LIQUID, CORROSIVE, N.O.S.UNRTDG class 3 (subsidiary risks class 8) (pocket book (1997)), this substance seems to be considered as the class 8 since there is skin corrosivenesses (pocket book (1997)). Since there is no data about corrosion behavior, it cannot be classified.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
From both the upper limit and lower limit of the rat 2 examination (the Health, Labor and Welfare Ministry reports (2005)) and LD50 value of ACGIH (2001), it was set as Category 4 based on LD50=1522 mg/kg calculated by the technological guideline.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
It is thought that the inhalation test was done with vapor since saturated vapor pressure concentration of this substance is 8050ppm. Since rat LC50 value was not acquired, it was classified as Category 4 based on LC50 = 12mg/L (equivalent: 2544ppm) obtained by having converted mice LC50 value in a 2 hour inhalation test into 4 hour inhalation.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was classified as Category 3 based on the result of "mild" in the skin irritation study on rabbits (RTECS (2004)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
From statements that although a corneal edema was acknowledged in 40ppm, it recovered in several hours, and that although the stimulation was felt for the ophthalmic in 50-100ppm, the stimulation in 50ppm was small in humans (ACGIH (2001)), it was taken as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - We have a negative result by the in vitro mutagenicity test (Health, Labor and Welfare Ministry reports (2005)), however, we found no in vivo test data. Therefore we could not classify it for the insufficiency of data.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the description of little decrease children count and live born count with dose causing slight toxicity to parent animals in rat examination (Health, Labor and Welfare Ministry reports (2005)), it is classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is the description that there is the irritation to nose and throat, and appearance of cough (ACGIH (2001), HSDB (2003)), and it is classified into Category 3 (respiratory irritation). In addition, although there is the description that there is lethargica, bleary eyes in human (ACGIH (2001)), it is unknown that it is single dose or repeated dose, and it is not used to categorize because there is no detail data.
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It was classified to as Category 2 (nervous systems) based on the statement that in the dosage of guidance value within the limits of Category 2 to rat, symptoms such as cage licking, chewing behavior, tremor, momentum decreases, crouching position and ptosis etc. are observed (Health, Labor and Welfare Ministry reports (2005)). In addition, although there was a statement that lethargy or blear in his vision was observed in humans (ACGIH (2001)) , it was unknown whether it is a single dose or it was a repeated doses, and there was no detailed data, so it was not use for the classification.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 72-hour ErC50>53mg/L of algae (Selenastrum) (MOE eco-toxicity tests of chemicals, 2002).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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