GHS Classification Result

Chemical Name：2-Butanone, peroxide
CAS：1338-23-4

Result：
ID: 670
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - UNRTDG No. 3105, Class: 5.2
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible - - - - Although it was thought that it was diluted with a dilution agent with high flash point (for example, dimethyl phthalate with 146 degC of flash point (Merck13th, 2001)), it was presupposed that it can not be classified since the flash point of a mixture with methyl-ethyl-ketone peroxide is unknown.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Classified in organic peroxidies
9 Pyrophoric liquids Not classified - - - - UNRTDG Class: 5.2(No.3105)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified - - - - UNRTDG No. 3105 Class: 5.2
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Type B, Type D or Type E Danger H241: Heating may cause a fire or explosion P411+P235: Store at temperatures not exceeding ... degC/... degF. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P234: Keep only in original container.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P410: Protect from sunlight.
P420: Store away from other materials.
P501: Dispose of contents/container to ... 		The United Nations number and the GHS classification are decided as follows by methyl ethyl ketone peroxide and diluent ratio; Diluent type A >=48%, Available oxygen >10% and <=10.7%, UNRTDG No.3101, Class:5.2, GHS Classification, Organic peroxides type B Diluent type A >=55%, Available oxygen <=10%, UNRTDG No.3105, Class:5.2, GHS Classification, Organic peroxides type D Diluent type A >=60%, Available oxygen <=8.2%, UNRTDG No.3107, Class:5.2, GHS Classification, Organic peroxides type E.
16 Corrosive to metals Not classified - - - - UNRTDG No.3105, Class: 5.2

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		It was set as Category 4 based on marginal lower confidence limits 407 mg/kg. This value is average of rat oral LD50= 484, 681, and 407mg/kg(ACGIH (2001) and PATTY (5th, 2001)).
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was set as Category 5 based on rat percutaneous LD50 value = 4000mg/kg (PATTY (5th, 200)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified as Category 2 based on 200ppm: the confidence bounds lower bound of the average value of at inhalation LC50 = 200ppm (ACGIH (2001)), 945 and 4587ppm (Patty (2001)).
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		There is a statement of "very strong stimulative substance" (PATTY (5th, 2001, vol.5, p1155)). But it was classified as Category 2 because there was no statement about irreversible pathological change, and there was a statement of "stimulativeness" (DFGOT vol.3 (1991, p250)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		It was set as Category 1 based on the description of "caustic" (PATTY (5th, 2001, vol.6, p1155)), "very severe irritation" (DFGOTvol.3 (1991, p250)) and "causing a critical injury to a rabbit eye" (HSDB (2003)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is the description that "there is the hyperemia with bleed in the lung in the 4-hour inhalation test of rat,"(ACGIH (2001)) and "the respiratory irritation substance"(PATTY (5th, 2001, vol. 6, p1203)), it is classified into Category 1 (respiratory systems). Although there is the report about the symptom in the case of oral ingestion in human, it is the nonspecific effect to organs by massive ingestion, and it is classified based on the animal test information.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified to as Category 2 based on the statementof "the fatty degeneration of liver and degeneration of kidney function are seen in the oral administration test with 97mg/kg of methyl ethyl ketone peroxide to the rat for seven weeks (ACGIH (2001)) ." Based on the statement with "changes in the tissues of the spleen and marrow (spleen hematopoietic cell proliferation and bone marrow hyperplasia) which were found out in the dermal administration test to rats and mouse is a secondary reactions" (ACGIH (2001) and NTP TR18 (1993)), changes in tissues of the spleen the and marrow is not used as a basis of a classification.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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