GHS Classification Result

Chemical Name：Hexanoic acid, 2-ethyl-
CAS：149-57-5

Result：
ID: 669
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Not classified because of its flash point: 118 to 120degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 371degC (ICSC (J), 1996; Solvent Pocket Book , 1997)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was set as Category 5 based on LD50=2093 mg/kg calculated by 4 examination result (3000, 3200, 1600, and 3000 mg/kg) (ACGIH (2001) and PATTY (5th, 2001)) of rat LD 50.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		There are two test results of rabbit LD50 (1140 and 1260mg/kg). It was set as Category 4 based on the lower value of LD50 = 1140mg/kg (ACGIH (2001)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - The saturated vapor pressure concentration of this product is 40ppm (20degC), and it is presumed that the inhalation test was done in mist conditions. Since there is no vapor data, it cannot be classified.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Considered more than Category 4 from rat inhalation LC0 >3.54mg/L.. But data is insufficient, it cannot be classified.
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the statement that necrosis, eschar, corrosion, etc. were observed in the tests on rabbits and guinea pigs (PATTY (5th, 2001) and IUCLID (2000)), it was classified as Category 1A-1C.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		It was set as category 1 based on the statement as which stimulativeness, a necrosis of the cornea, etc. were regarded (ACGIH (2001) and IUCLID (2000)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Based on the negative statement (NICNAS (2005)) of the maximisation test using a guinea pigs, it was put outside of the Category.
5 Germ cell mutagenicity Classification not possible - - - - Since we found no in vivo examination and we found only the result of the in vitro examination, we presupposed that we could not categorize it by the technical guideline.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description of observing dose-dependent skeltal malformation as clubfoot, polydactyly and fibula loss etc. in rat teratogenecity test with dose no affecting maternal animals (PATTY (5th, 2001)), it is classified into Category 1B. In addition, there is the existing classifications of EU-Annex 1:Repr.Cat.3;R63.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - NOAEL in the feeding administration tests for 13 weeks using rats and mice is mentioned to be 200 mg/kg/day and more (PATTY (5th, 2001)). Since this dose exceeded the upper limit of the Category 2 guidance value range, it is considered the outside of Category.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48-hour EC50=85.4mg/L of Crustacea (Daphnia magna) (IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3, since acute toxicity was Category 3 and rapid degradability is unknown, though supposed less bio-accumulative (log Kow=2.64 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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