GHS Classification Result

Chemical Name：2-Norbornene, 5-ethylidene-
CAS：16219-75-3

Result：
ID: 664
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - Classification not possible due to lack of data, though the substance contains unsaturated C-C bonds as chemical groups associated with explosive properties present.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Category 3 because of its flash point: 38 to 38.33degC(Hommel, 1991)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though the substance contains unsaturated C-C bonds as chemical groups with self-reactive properties present.
9 Pyrophoric liquids Not classified - - - - Flash point: 272degC (SIDS, 2004)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was set as Category 5 based on LD50=2276 mg/kg calculated by LD50 value of 4 examination of the oral administration in rats of SIDS (2004), ACGIH (2001), and PATTY (5th, 2001).
1 Acute toxicity （Dermal） Not classified - - - - Based on the description of LD50 = 8253mg/kg in rabbit percutaneous toxicity studies (ACGIH (2001)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Since the saturated vapor pressure concentration of this product is 5518ppm, it is thought that inhalation toxicity study was done with vapor. Based on the data 2717ppm of the male (SIDS (2004)) which is the lowest among LC50 values for rat 4-hour inhalation test for both sex, it was classified as Category 4 based on the technological direction.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. There are descriptions that it has skin irritativeness and caused redness on humans (PATTY (5th, 2001)), and the result of the rabbit skin irritation study with four hour application was "slight" to "mild" (SIDS (2004)). Therefore, it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on the statement of "slight eye irritant" in a rabbit eye irritation test (SIDS (2004)), and based on that irritation was acknowledged in the eye by humans test (ACGIH and (2001), PATTY (5th, 2001)), it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Based on the negative statement in the rat dominant lethality examination (SIDS (2004)), we classified it as Out Of Category.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there is the description that there is the effect to parent reproduction (testicular tissue disorder, ovarian dysfunction and the decrease of the implantation rate and of the delivery rate), and the neonatal growth (the reduction of total delivery count, the number of the alive neonatal and the number of 4-day-long alive neonatal) with dose causing the general toxicity to parent animals (the Health, Labor and Welfare Ministry reports (2005), SIDS (2004), HSDB (2005)), it is classified into the Category 2
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 2 (gastrointestinal tract), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (central nervous system)
H371: May cause damage to organs (gastrointestinal tract)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		There is the description that there are the malevolence/vomiting, headache, confusing, dyspnoea (PATTY (5th, 2001)), and it is classified into Category 1 (central nervous system). And there is the description that there is the irritation to nose, throat in the steam exposure to human, and it is classified into Category 3 (respiratory irritation). There is the description that there is the diarrhea, gastrointestinal bleeding, and gastrointestinal distension in the dose of the guidance value range (2000 > = C > 1000mg/kg) of Category 2 in the dermal administration to rabbit. So it is classified into Category 2 (digestive tract).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the repeated administrate oral toxicity examination using a rat, hepatocyte vacuolation is seen by the dosage in the range of Category 2 of a guidance value (10-100 mg/kg/day) (Health, Labor and Welfare Ministry reports (2005)), and in rat repeated administrate inhalation toxicity studies, morphological change and hardening of liver, and the degeneration of hepatocytes were observed with dosage (1.165 mg/L/6 hr/day) little higher than the upper limit of the range of Category 2 of a guidance value (0.2-1.0 mg/L/6 hr/day) (SIDS (2004)). Also in dog repeated dose inhalation toxicity studies , fibrillization of liver, the increase in deviation enzyme, and hyperplasia briliary tract are mentioned with the dosage of guidance value within the limits of Category 2(SIDS (2004)). It was classified to as Category 2 (liver) based on the above information.
10 Aspiration hazard Category 1 Danger H304: May be fatal if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into Category 1 based on the description of severe pneumonia by aspiration in human (PATTY (5th, 2001)), and the description that when the fluid is swallowed, there is a risk of chemical pneumonitis by aspiration (ICSC (J), (1999)).

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour EC50=3.3 mg/L of Crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals, 1998).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2 and not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bio-accumulative (BCF=160 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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