GHS Classification Result

Chemical Name:4,4'-(4-iminocyclohexa-2,5-dienylidenemethylene)dianiline hydrochloride
CAS:569-61-9

Result:
ID: 658
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - No data available
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - Reducing substance (IARC 57 (1993))
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Melting point: 268-270degC (decomposes) (HSDB, 2005). Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. SPECIES: Mouse ENDPOINT: LD50 VALUE: 5000 mg/kg REFERENCE SOURCE: RTECS(2004)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - No data available
3 Serious eye damage/eye irritation Classification not possible - - - - As a result of applying to eye of rabbit, it is only described as "injurious to rabbit eyes"(HSDB (2005)), and since Category was not able to be specificked. So it cannot classify.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
We categorized it as Category 2. Since the DNA damage induction was acknowledged by an in vivo genotoxicity study (comet study: single cell gel electrophoresis assay of mouse) (RTECS (2004), and we found the positive result in the in vitro mutagenicity test of multiple indices (Reverse mutation (- S9), Forward mutation, gene mutation for lymphoma cell of the mouse etc) (IARC 57 (1993)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as category 2. Based on being classified into 2B (1993) according to IARC, into 2B (2005) according to Occupational Health Society, and into R (1996) according to NTP.
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - In the test by 13-week (about 90 days) feeding administration using rats and mice, remarkable influence is not acknowledged except for the goiter and the fatty degeneration of a liver in 4000 ppm and hyperplasia of thyroid gland and the basophilic hyperplasia in hypophysis in more than 2000 ppm (= approx. 200 mg/kg) in the case of the rat. Furthermore, for two-year carcinogenicity tests carried out under the same conditions in the rats and mice, a significant toxic change of non-neoplastic is not described, although the increase mortality rate accompanying increased the frequency of tumors is mostly seen in 1000-2000 ppm (= approx. 50-150 mg/kg). As mentioned above, since serious toxic impact dose through oral exposure for 90 days was considered to be around 2000 ppm (= approx. 200 mg/kg), it carried out the outside of Category with reference to the guidance value.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

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