GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Dinitrogen oxide
CAS：10024-97-2
Result：
| ID: | 656 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Flammable gases （including chemically unstable gases） | Not classified | - | - | - | - | Non-combustible |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Category 1 |
|
Danger | H270: May cause or intensify fire; oxidizer |
P370+P376: In case of fire: Stop leak if safe to do so. P220: Keep/Store away from clothing/.../combustible materials. P244: Keep reduction valves free from grease and oil. P403: Store in a well-ventilated place. |
Oxidizing because of UNRTDG Subsidiary risks Class: 5.1 and GHS, 1st, P.58 (2.4.4.2) |
| 5 | Gases under pressure | Compressed gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | Transported as refrigerated liquefied gases (UNRTDG) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Gas (GHS definition) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Gas (GHS definition). Inorganic substance. |
| 16 | Corrosive to metals | Not applicable | - | - | - | - | Test methods applicable to gas substances are not available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not applicable | - | - | - | - | Since there is no suitable liquid solvent, oral administration is impossible. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | There is no examination data. But based on the information that there is no skin irritation (DFGOTvol9. (1998)), it was classified as out of Category. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | It gave a negative result in the in vitro examination (ACGIH (2001)). However, we found no valid in vivo data, therefore we could not classify it. |
| 6 | Carcinogenicity | Not classified | - | - | - | - | Since it was A4 in ACGIH which is an evaluation organization, it carried out the outside of Category. |
| 7 | Reproductive toxicity | Category 1A |
|
Danger | H360: May damage fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
It is classified into the Category 1A because natural abortion by insufflations increased in the case of the female workers working in the dental clinics (ACGIH (2001)). An animal experiments in rat shows embryotoxicity, the ferotoxity and the skeltal malformation. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects） |
|
Warning | H336: May cause drowsiness or dizziness (narcotic effects) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
There is anesthetic action with the case of animals and humans (DFGOT vol.9 (1998)), it is classified into Category 3. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood, nervous system, liver, kidney) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (blood, nervous system, liver, kidney) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the information that there is a disease of a hematopoietic system and the information that the obstacle to liver, the kidney, and a nervous system appears by occupational exposure when used with dentist as an anesthetic drug in human cases, it was classified to as Category 1 (blood, a nervous system, liver, kidney) (ACGIH (2001)) |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Gas (GHS definition) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |