NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Monosodium sulfite
CAS：7631-90-5

Result：


ID:	639
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Aqueous solution
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Aqueous solution
5	Gases under pressure	Not applicable	-	-	-	-	Aqueous solution
6	Flammable liquids	Not classified	-	-	-	-	Aqueous solution. Non-combustible
7	Flammable solids	Not applicable	-	-	-	-	Aqueous solution
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9	Pyrophoric liquids	Not classified	-	-	-	-	Non-combustible solution
10	Pyrophoric solids	Not applicable	-	-	-	-	Aqueous solution
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	The aqueous solution is stable.
13	Oxidizing liquids	Not classified	-	-	-	-	Reducing substance
14	Oxidizing solids	Not applicable	-	-	-	-	Aqueous solution
15	Organic peroxides	Not applicable	-	-	-	-	Inorganic substance
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Category 4 based on SPECIES: Rat; ENDPOINT: LD50; VALUE (Average): 1310mg/kg
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Aqueous solution
1	Acute toxicity （Inhalation: Vapours）	Not applicable	-	-	-	-	Aqueous solutions. Volatilizing is mainly vapor.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	It has not stimulation in animal experiments. But there is information that it causes irritation on humans with concentrated solution, and it is designated as class 8 also in UN hazardous material transportation.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	Although there is case of humans (ACGIH (2002)), it is supposed that the animal experiment result by solution is no stimulating.
4	Respiratory sensitization	Category 1		Danger	H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled	P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ...	As human epidemiology information, a small number of allergy case caused by inhalation, skin contact and intake has been reported. It is said that it happens to the humans of sulfite oxidase deficiency. Although the occurrence rate was not high, it was referred to as Category 1 by expert judgment.
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	As human epidemiology information, a small number of allergy case caused by inhalation, skin contact and intake has been reported. It is said that it happens to the humans of sulfite oxidase deficiency. Although the occurrence rate was not high, it was referred to as Category 1 by expert judgment.
5	Germ cell mutagenicity	Not classified	-	-	-	-	The in vivo result was, "it gave negative for the mouse and over generation mutagenicity tests of mouse." Although we found the positive result for in vitro test, we classified it as "Out Of Category" by the technical guideline. [Based on the expert's opinion, we corrected the basic sentences.]
6	Carcinogenicity	Not classified	-	-	-	-	Since it is class 3 by IARC and is A4 by ACGIH, it carried out "Category Outside."
7	Reproductive toxicity	Not classified	-	-	-	-	Since the adverse effects was not reported in multi-generation test, it carried out "Category Outside."
8	Specific target organ toxicity - Single exposure	Category 3 （Respiratory tract irritation）		Warning	H335: May cause respiratory irritation (respiratory tract irritation)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	Since there was respiratory stimulas information by the human aerosol exposure, it was set as category 3 (respiratory tract irritation).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (respiratory system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	It was classified to as "Category 1" since there is a report of an asthmatic among laundry workers and a food ingesting person (ACGIH (2001)). (Modified by expert judgment)
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Not classified	-	-	-	-	It carried out the outside of Category from 48-hour LC50=119000microg/L of Crustacea (Daphnia magna), and others (AQUIRE, 2003).
11	Hazardous to the aquatic environment （Long-term）	Not classified	-	-	-	-	Since not water-insoluble (aqueous solubility =540 g/L (IUCLID, 2000)) and acute toxicity is low.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）