GHS Classification Result

Chemical Name:Acetone
CAS:67-64-1

Result:
ID: 635
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Flash point: -20degC (<-23degC), Boiling point: 56.5degC (>-35degC)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 465degC and liquid
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Not classified - - - - Steel and aluminum can be used as a container. (Hommel, 1991)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - SPECIES: Rat ENDPOINT: LD50 VALUE: > 5000 mg/kg REFERENCE SOURCE: SIDS (1999), ACGIH (2001)
1 Acute toxicity (Dermal) Not classified - - - - Based on rabbit LD50 >5000mg/kg (ACGIH (2001), SIDS (1999)), it was set as the outside of Category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not classified - - - - Rat LC50: 32000ppm (75.8mg/L) (SIDS (1999)) Since this value was outside of the range of 2.5 times of judgment criteria of Category 4 (50mg/L), it was classified as out of Category. (20degC. The saturated air of acetone are 230000ppm, and it is considered that all inhalation toxicity study was done in the state of steam.)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - It was classified as out of Category from the statement of having no stimulativeness on rabbit skin (EHC 207 (1998)) and (SIDS (1999)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Vapor stimulates public eye. However, if exposure stops, irritation will not follow (ATSDR (1994)). The result of severe is reported in the rabbit (ACGIH (2001)). Although a corneal epithelium is destroyed, substrate is not destroyed, and destruction of a corneal epithelium will be recovered in 4-6 days. Acetone is not corrosive eye irritations (SIDS (1999)). It was set as Category 2B from the above description.
4 Respiratory sensitization Classification not possible - - - - Since there is no data, the respiratory sensitization cannot be classified.
4 Skin sensitization Not classified - - - - Since it was indicated negative by the Mouse ear swelling test and Guinea pig maximization test(SIDS (1999)), the skin sensitization was put outside of the Category.
5 Germ cell mutagenicity Not classified - - - - We found the negative results for in vivo micronucleus examination (SIDS (1999), EHC 207 (1998)), therefore we classified it as Out Of Category by the technical guideline.
6 Carcinogenicity Not classified - - - - It is ACGIH A4(ACGIH (2001)), and categoried the outside of Category from the technical indicator.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is a report that he has no effect on a miscarriage in an epidemiological study (ATSDR, 1994). It is reported of slight developmental toxicity (decrease of embryo weight) in rat high concentration exposure (11000 ppm (20 mg/L)) (EHC, 207 (1998)) and of the decrease of embryo weight and the increase of late embryo absortion rate in mouse high concentration exposure (6600 ppm (15.6 mg/L)) (EHC, 207 (1998)). There is a description that study is still more nearly required, for an animal with humans (EHC). And it is classified into the Category 2 the above thing.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation, Narcotic effects) Warning H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the descriptions that irritation in the human throat is caused by 1200ppm exposure (ACGIH (2001)), that irritation is caused in the nasal cavity, throat and trachea by 1190 and 2400mg/m3/6h exposure to humans (ECH 207 (1998)), and that irritation was caused in the throat by 1000ppm/4h exposure (ECH 207 (1998)). So it was set as Category 3 (airway irritation). And the discriptions that a male who drank 200ml fell coma (recovering his conciousness in 12 hours), and that a worker exposed to 12000ppm experienced headache, dizziness, leg weakness and fainting (ACGIH (2001)). So it was also set as Category 3 ( anesthetic actions) based on the descriptions that a male who drank 200 ml fell coma, recovering his conciousness in 12 hours, and that a worker exposed to 12000 ppm experienced headache, dizziness, leg weakness and dead faint(ACGIH (2001)).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It was classified into Category 2, since by the examination using volunteers, the significant increase in white corpuscles and an eosinophil and the significant reduction of a phagocytosis of a neutrophil were observed in the exposure group with 500 ppm, 6 hours/day for 6 days (ACGIH (2001)). In the examination using the rat and the mouse, although it was a dose greatly beyond guidance limits, the similar haematological changes like in humans was admitted (SIDS (1999)). Since in other examination using a rat and a mouse , each is over the guidance limits (ACGIH (2001)),(SIDS (1999)) and there is also no example of a report in humans, they were not adopted as a classification basis.
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ...
The calculated dynamic viscosity is 0.426mm2/sec and there was not the animal data of chemical pneumonia, however, it was the ketone of under C13, therefore it was classified into Category 2.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 96-hour LC50>100mg/L of fishes (Fathead minnows) (EHC207, 1998).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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