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GHS Classification Result

Chemical Name：Butyl acrylate
CAS：141-32-2

Result：


ID:	630
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not classified	-	-	-	-	Not classified based on UNRTDG Class: 3, though containing unsaturated C-C bonds as chemical groups associated with explosive properties present.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3		Warning	H226: Flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Category 3 because of its flash point: 29degC
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not classified	-	-	-	-	Not classified based on UNRTDG Class: 3, though containing unsaturated C-C bonds as chemical groups associated with self-reactive properties present
9	Pyrophoric liquids	Not classified	-	-	-	-	Flash point: 267degC (Hommel, 1991)
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Not classified because of UNRTDG Class: 3
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no -0-0- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 5	-	Warning	H303: May be harmful if swallowed	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	It was set as Category 5 based on LD50= 4349mg/kg calculated according by the technological guideline using 14 test results of rat LD50 (SIDS (2002), ECETOC JACC 27 (1994)).
1	Acute toxicity （Dermal）	Category 5	-	Warning	H313: May be harmful in contact with skin	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	It was set as Category 5 based on LD50 = 2054mg/kg calculated by the technical guideline using five test results of rabbits (SIDS (2002), ECETOC JACC 27 (1994)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Category 3		Danger	H331: Toxic if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It seems that the inhalation test was done with vapor since saturated vapor pressure concentration was 5248ppm. From eight rat test results (SIDS (2002), ECETOC JACC 27 (1994)) , it was classified as Category 3 based on LC50 = 2026ppm converted from LC50 = 10.6mg/L calculated based on the technological direction.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	Based on statement that moderate to severe erythema and dropsy are observed on rabbits (SIDS (2002)), that there is skin irritation on humans and that the skin disease of papular erythematous was observed (SIDS (2002), DFGOT vol.5 (1993)), and the fact that it is classified into Xi; R36/37/38 in EU (EU-Annex I (2005)), it was classified as Category 2.
3	Serious eye damage/eye irritation	Category 2A-2B		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	There is a statement that in the rabbit, irritation was indicated in the eye (ECETOC JACC 27 (1994), SIDS (2002)), slight muddiness was produced in corneal (ECETOC JACC 27 (1994), SIDS (2002)), and moderate to serious injury was produced (SIDS (2002)) etc., and it is classified into X;R36/37/38 in EU (EU-Annex I (2005)). So it was set as Category 2A-2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	The guinea pigs indicate prolonged contacted skin hypersensitivity. There are statements which show sensitization (SIDS (2002)), ECETOC JACC 27 (1994), ACGIH (7th, 2003). Many statements say that this product causes allergic contact dermatitis based on the result of a patch test in humans ( SIDS (2002)), DFGOT vol.5 (1993), IARC71 (1999), and ECETOC JACC 27 (1994). It is mentioned by the Japanese occupation and the environmental allergology meeting as a sensitizing chemical (ALGY society's (feeling) substance list (proposal)). It is classified as R43 by EU (EU-Annex I (2005))..Based on all of them it was referred to as Category 1.
5	Germ cell mutagenicity	Not classified	-	-	-	-	We found no human over generation epidemiology, the over generation mutagenicity test, and the productive cell in vivo mutagenicity test result. And it gave negative in the in vivo mutagenicity tests (chromosomal aberration test using mammalian bone marrow cells) using the somatic cells (SIDS (2002), ACGIH (7th, 2003), ECETOC 27 (1994), and DFGOT vol.5 (1993)). Therefore we classified it as Out Of Category by the technical guideline.
6	Carcinogenicity	Not classified	-	-	-	-	Based on what it is classified into 3 according to IARC (IARC 71 (1999)), and is classified into A4 according to ACGIH (ACGIH (7th, 2003)), it considered as the outside of Category.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Since there is the description that there is the embryonic lethality, the decreased neonatal weight and decrease of viable fetus in rat inhalation test at dose causing general toxicity to parent animals (SIDS (2002), ECETOC JACC 27 (1994)), and there is the description that there is the embryonic lethality, the decreased neonatal weight and teratogenicity in the mouse oral administration and inhalation test (SIDS (2002), ECETOC JACC 27 (1994), PATTY (5th, 2001)), it was classified into the Category 2.
8	Specific target organ toxicity - Single exposure	Category 3 （Respiratory tract irritation）		Warning	H335: May cause respiratory irritation (respiratory tract irritation)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the statements that irritation to the respiratory tract in rats was identified (SIDS (2002)) and that nasal discharges increased and hyperemia of the mucous membranes was observed (SIDS (2002), ECETOC JACC 27 (1994)), it was set as Category 3 (Airway irritation).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Although lack of a cell and the hyperplasia which compensates this on the olfactory sensory epitheliums of nose were seen in a rat by the dose within the limits of the guidance value (0.2-1.0 mg/L) of Category 2 (DFGOT vol.12 (1999)), it is affected in the long term exposure such as 12 months, and there is a statement that effects on the olfactory in human are reversible (SIDS (2002)). In addition, although there is also a statement of weight reduction etc. by the dosage of guidance value within the limits of Category 2 (SIDS (2002)), the extent is unknown. According to these things, it was presupposed to be unclassified due to lack of data.
10	Aspiration hazard	Category 2		Warning	H305: May be harmful if swallowed and enters airways	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P331: Do NOT induce vomiting. P405: Store locked up. P501: Dispose of contents/container to ...	Category 2 because of "possible to classify into Aspiration hazard." (ICSC Card)

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 2	-	-	H401: Toxic to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	It was classified into Category 2 from 72-hour ErC50=1.7mg/L of algae (Selenastrum) (MOE eco-toxicity tests of chemicals, 1999).
11	Hazardous to the aquatic environment （Long-term）	Not classified	-	-	-	-	Since rapidly degrading (BOD: 61.3% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=2.36 (PHYSPROP Database, 2005)).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）