GHS Classification Result

Chemical Name：Rotenone
CAS：83-79-4

Result：
ID: 629
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available by regulated examination methods, though "Flammable" (ICSC (J) (2000))
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Calculated based on rat LD50 values: 25 to 132 mg/kg (ACGIH 7th, 2001, DFGOT vol.19, 2003) and 60mg/kg (NTP TR320, 1988). Since the calculation value was lower than these lowest values, 25 mg/kg of lowest value was adopted, and set it as Category 2.
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 2 based on rabbit LD50 value: 100 - 200mg/kg (DFGOT vol.19, 2003).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - There was data with rat LCLo (30 minutes) value: 0.5mg/L (4-hour equivalent 0.06 mg/L) (RTECS (2006)). But category cannot be specified since LC50 value was unknown. Therefore, it cannot be classified since data is insufficient.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was classified as Category 2 from description that it stimulated rabbit skin seriously (DFGOT (vol.19, 2003)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		It was set as Category 2A from description that the eye of the rabbit was stimulated strongly (ACGIH (7th, 2001) and DFGOT (vol.19, 2003)) .
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Not classified - - - - Since it was classified into A4 (ACGIH 7th, 2001) according to ACGIH, it carried out the outside of Category.
7 Reproductive toxicity Not classified - - - - Based on the description that it was not observed spcific reproductive toxicity at dose causing general toxicity to parent animals in pregnant rat oral administration test (ACGIH (7th, 2001), DFGOT (vol.19, 2003), IRIS (2006) and NTP TR320 (1988)) and in rat two-generation reproduction test (IRIS (2006)) , it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		According to the description that nausea, vomiting and shivering are caused by acute exposures to humans (NTP TR320 (1988)), nerve systems were considered to be the target organs and set as Category 1 (nervous systems). Moreover, it was set as Category 3 (respiratory tracts irritation), based on the description that the airway is irritated (ICSC (J) (2000), HSFS (2000), and SITTIG (4th, 2002)).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, kidney), Category 2 (bone marrow, gastrointestinal tract) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney)
H373: May cause damage to organs through prolonged or repeated exposure (bone marrow, gastrointestinal tract) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified to as Category 1 (liver, kidney) because of description that the fatty degeneration of the kidney and liver was acknowledged by the dosage of the guidance value range of Category 1 in the oral feeding administration tests using the dog (ACGIH (7th, 2001)) and, because of description that the atrophy of the bone marrow and inflammation and hyperplasia of the forestomach were acknowledged by the dosage of the guidance value range of Category 2 in the oral feeding administration tests using the rat (NTP TR320 (1988), ACGIH (7th, 2001), DFGOT (vol.19, 2003)), it was classified to as Category 2 (marrow, gastrointestinal tract).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.0283microL/L of fishes (Rainbow trout) (AQUIRE, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=4.1 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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